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Results for "

COX inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (473) 5-HT Receptor (1) Acyltransferase (2) Akt (4) Aldose Reductase (1) AMPK (4) Amyloid-β (2) Antibiotic (5) Apoptosis (79) Autophagy (36) Bacterial (23) Bcl-2 Family (3) Beta-secretase (1) Biochemical Assay Reagents (1) Calcium Channel (6) CaMK (1) Carbonic Anhydrase (5) Caspase (6) Chloride Channel (6) Cholinesterase (ChE) (2) CMV (1) Cytochrome P450 (3) Dengue virus (1) Drug Metabolite (7) EGFR (1) Endogenous Metabolite (47) Epoxide Hydrolase (1) ERK (4) Estrogen Receptor/ERR (3) FAAH (4) Ferroptosis (9) Flavivirus (1) Fungal (3) GABA Receptor (1) GLUT (2) HDAC (2) Histone Acetyltransferase (6) HSV (1) IGF-1R (1) IKK (4) Influenza Virus (10) Interleukin Related (4) Isotope-Labeled Compounds (44) JNK (1) Leukotriene Receptor (2) Lipoxygenase (30) LOX-1 (1) mAChR (1) Macrophage migration inhibitory factor (MIF) (2) MEK (1) Melatonin Receptor (4) Microtubule/Tubulin (2) Mitophagy (13) MMP (5) NF-κB (50) NO Synthase (19) NOD-like Receptor (NLR) (1) Notch (1) p38 MAPK (10) Parasite (17) PGE synthase (9) Phospholipase (4) PI3K (2) PKA (1) PKC (1) Potassium Channel (6) PPAR (7) Progesterone Receptor (2) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (2) RAR/RXR (1) Reactive Oxygen Species (14) Ribosomal S6 Kinase (RSK) (2) SARS-CoV (1) Sirtuin (1) SOD (1) Sodium Channel (2) Src (1) STAT (1) Survivin (1) TNF Receptor (6) Toll-like Receptor (TLR) (2) Topoisomerase (2) Transthyretin (TTR) (1) TRP Channel (2) Tyrosinase (1) VEGFR (2) Virus Protease (7) Wnt (2) Xanthine Oxidase (1) β-catenin (2)
By Research Areas:	Cancer (204) Cardiovascular Disease (31) Endocrinology (7) Infection (31) Inflammation/Immunology (425) Metabolic Disease (24) Neurological Disease (32)
Click Chemistry:	Alkynes (1)

517

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

106

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: COX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14445

FK 3311

COX-2 inhibitor V
COX Inflammation/Immunology

FK 3311 (COX-2 Inhibitor V) is a selective inhibitor of COX-2 with antiinflammatory agent.

FK 3311 COX-2 inhibitor V	COX	Inflammation/Immunology
FK 3311 (COX-2 Inhibitor V) is a selective inhibitor of *COX-2* with antiinflammatory agent.

HY-117368

AL-8417 (2R)-AL-5898	COX	Inflammation/Immunology
AL-8417 ((2R)-AL-5898) is a potent inhibitor of Cyclooxygenase (COX), with IC₅₀ of 120 μM, that plays an important role in inflammatory response .

HY-113807

ZLJ-6	COX Lipoxygenase	Inflammation/Immunology
ZLJ-6 is a dual *COX* and 5-LOX inhibitor with oral activity. The IC₅₀ values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity .

HY-163355

COX-2/15-LOX-IN-5	COX Lipoxygenase NF-κB	Inflammation/Immunology
COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities .

HY-152120

(±)-Aiphanol Aiphanol	COX VEGFR	Inflammation/Immunology Cancer
(±)-Aiphanol is a newly discovered stilbenolignan analog. (±)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of *COX-1* and *COX-2. The inhibitory effect on COX-1 (IC₅₀ = 1.9 μM) is particularly strong, while the effect on COX-2 (IC₅₀= 9.9 μM) is relatively weak .(±)-Aiphanol effectively inhibits* VEGFR2 (IC₅₀=0.92 µM). (±)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±)-Aiphanol is orally active .

HY-B0227

Ketoprofen 3 Publications Verification RP-19583	COX	Metabolic Disease Inflammation/Immunology Cancer
Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC₅₀ values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .

HY-B0227A

Ketoprofen (lysinate) RP-19583 (lysinate)	COX	Metabolic Disease Inflammation/Immunology
Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC₅₀ values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .

HY-W268542

4-Acetylaminoantipyrine	COX SOD PGE synthase	Inflammation/Immunology Cancer
4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX) . 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD . 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation .

HY-B1279

Metamizole sodium hydrate 1 Publications Verification Dipyrone hydrate	COX Apoptosis	Inflammation/Immunology
Metamizole sodium hydrate (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor.. Metamizole sodium hydrate can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium hydrate has anti-inflammatory and antioxidant activities. Metamizole sodium hydrate is an antipyretic, analgesic and spasmolytic agent. Metamizole sodium hydrate can be used in research to relieve a variety of pain .

HY-B1279A

Metamizole sodium 1 Publications Verification Dipyrone	COX Apoptosis	Inflammation/Immunology
Metamizole sodium (Dipyrone) is an orally active cyclooxygenase (COX) inhibitor. Metamizole sodium can inhibit cell proliferation and promote cell apoptosis. Metamizole sodium has anti-inflammatory and antioxidant activities. Metamizole sodium is an antipyretic, analgesic and spasmolytic agent. .Metamizole sodium can be used in research to relieve a variety of pain .

HY-155764

COX-1/2-IN-4	COX	Cancer
COX-1/2-IN-4 (compound 2b) is anCOX inhibitorwith IC₅₀ values of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme , respectively. COX-1/2-IN-4showsmoderateanticanceractivity against COLO205 and B16F1 cancer cell lines with IC₅₀ values of 30.79 and 74.15 μM, respectively .

HY-163509

COX-2-IN-43	COX Apoptosis	Cancer
COX-2-IN-43 (Compound MYM4) is a *COX-2* inhibitor (IC₅₀: 0.983 and 0.247 μM for COX-1 and COX-2 respectively). COX-2-IN-43 inhibits cancer cell proliferation and colonization, induces apoptosis .

HY-115976

COX-2-IN-10	COX	Inflammation/Immunology
COX-2-IN-10 is a potent *COX-2* inhibitor. COX-2-IN-10 inhibits the production of PGE₂ in concentration dependent manner (IC₅₀=2.54 µM). COX-2-IN-10 inhibits the expression of iNOS and *COX-2* on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β .

HY-162167

COX-1-IN-1	COX	Cardiovascular Disease Neurological Disease
COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase (COX), with IC₅₀s of 0.23 μM (COX-1) and >50 μM (COX-2), selective index (COX-2 IC₅₀/COX-1 IC₅₀) is 217. COX-1-IN-1 inhibits platelet aggregation .

HY-147719

COX-2-IN-16	COX	Inflammation/Immunology
COX-2-IN-16 (compound 2b) is a potent, selective and orally active *COX-2* inhibitor with an IC₅₀ of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity .

HY-115966

COX-1/2-IN-1	COX	Inflammation/Immunology
COX-1/2-IN-2 is a potent *COX1/2* inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC₅₀ values of 13.9 ± 3.21 µM and 6.4±0.74 µM, respectively .

HY-115967

COX-1/2-IN-2	COX	Inflammation/Immunology
COX-1/2-IN-2 is a potent *COX1/2* inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC₅₀ values of 9.7 ± 0.09 µM and 4.6 ± 1.45 µM, respectively .

HY-147693

COX-1/2-IN-3

COX Inflammation/Immunology

COX-1/2-IN-3 (Compound 7a) is a COX-1 and COX-2 inhibitor. COX-2-IN-15 shows anti-inflammatory activity with low toxicity .

COX-1/2-IN-3	COX	Inflammation/Immunology
COX-1/2-IN-3 (Compound 7a) is a *COX-1* and *COX-2* inhibitor. COX-2-IN-15 shows anti-inflammatory activity with low toxicity .

HY-115866

COX-2-IN-6	COX	Cancer
COX-2-IN-6 (compound 10) is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. COX-2-IN-6 selectively targets COX-2 with an IC₅₀ of 0.84 μM and a Ki of 69 nM. COX-2-IN-6 also inhibits COX-2-driven PGE2 synthesis with an IC₅₀ of 0.60 μM .

HY-100580

Asaraldehyde Asaronaldehyde; Asaraldehyde; 2,4,5-trimethoxy-Benzaldehyde	COX	Inflammation/Immunology
Asarylaldehyde (Asaronaldehyde), a *COX-2* inhibitor, significantly inhibits cyclooxygenase II (COX-2) activity with an IC₅₀ value of 100 μg/mL .

HY-147961

COX-2-IN-23	COX	Inflammation/Immunology
COX-2-IN-23 (compound 9a) is a selective *COX-2* inhibitor with IC₅₀ values of 0.28 and 20.14 μM for COX-2 and COX-1. COX-2-IN-23 has anti-inflammatory activity and low ulcerogenic activity.

HY-161294

COX-2-IN-41

COX Cancer

COX-2-IN-41 (compound 5e) is a selective inhibitor of COX-2 (IC₅₀=1.74 μM). Compared with COX-1, the selectivity IC₅₀ (COX-1)/IC₅₀(COX-2) =16.32 .

COX-2-IN-41	COX	Cancer
COX-2-IN-41 (compound 5e) is a selective inhibitor of COX-2 (IC₅₀=1.74 μM). Compared with COX-1, the selectivity IC₅₀ (COX-1)/IC₅₀(COX-2) =16.32 .

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	COX Endogenous Metabolite	Inflammation/Immunology
Lornoxicam (Chlortenoxicam), a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID).

HY-U00275

COX-2-IN-1

COX Inflammation/Immunology

COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC₅₀ of 3.9 μM.
HY-150553

COX-2-IN-28

COX Inflammation/Immunology

COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC₅₀ values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively .

COX-2-IN-1	COX	Inflammation/Immunology
COX-2-IN-1 is potent and slective *COX-2* inhibitor with an IC₅₀ of 3.9 μM.

COX-2-IN-28	COX	Inflammation/Immunology
COX-2-IN-28 is a potent and selective *COX-2* inhibitor with IC₅₀ values of 0.054, 2.14, 13.21 µM for COX-2, 15-LOX, COX-1,respectively .

HY-153762

COX-2-IN-32	NO Synthase NF-κB COX	Inflammation/Immunology
COX-2-IN-32 (Compound 2f) is an iNOS and *COX-2* inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC₅₀: 11.2 μM) .

HY-150551

COX-2-IN-27	COX	Inflammation/Immunology
COX-2-IN-27 is a potent and selective *COX-2* inhibitor with IC₅₀ values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity .

HY-156254

COX-2-IN-35

COX Inflammation/Immunology

COX-2-IN-35 (compound 7) is a selective COX-2 inhibitor with an IC₅₀ of 4.37 nM. COX-2-IN-35 has anti-inflammatory activity .

COX-2-IN-35	COX	Inflammation/Immunology
COX-2-IN-35 (compound 7) is a selective *COX-2* inhibitor with an IC₅₀ of 4.37 nM. COX-2-IN-35 has anti-inflammatory activity .

HY-B0808S1

Oxaprozin-d5 Oxaprozinum-d₅; Wy21743-d₅	Isotope-Labeled Compounds COX NF-κB	Inflammation/Immunology Cancer
Oxaprozin-d₅ is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.

HY-145988

COX-2-IN-11	COX	Inflammation/Immunology
COX-2-IN-11 (compound 7b2) is a potent and selective inhibitor of *COX-2. COX*-2-IN-11 has the potential for the research of inflammation diseases .

HY-162244

COX-2-IN-40

COX Inflammation/Immunology

COX-2-IN-40 (compound 17) is a COX-2 inhibitor with the IC₅₀ of 14.86 μM. COX-2-IN-40 can be used for study of chronic pain .

COX-2-IN-40	COX	Inflammation/Immunology
COX-2-IN-40 (compound 17) is a *COX-2* inhibitor with the IC₅₀ of 14.86 μM. COX-2-IN-40 can be used for study of chronic pain .

HY-150550

COX-2-IN-26	COX	Inflammation/Immunology
COX-2-IN-26 is a potent, selective and orally active *COX-2* inhibitor with IC₅₀ values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile .

HY-157578

COX-2-IN-38

COX Inflammation/Immunology

COX-2-IN-38 (compound 52*) is a potent inhibitor of COX-2, with the IC₅₀ value of 79.4 nM .
HY-157583

COX-2-IN-39

COX Others

COX-2-IN-39 (compound 44) is a potent inhibitor of COX-2, with the IC₅₀ value of 0.4 nM .
HY-17479A

Amfenac Sodium Hydrate

COX Inflammation/Immunology

Amfenac Sodium Hydrate is a COX-2 inhibitor.

COX-2-IN-38	COX	Inflammation/Immunology
COX-2-IN-38 (compound 52) is a potent inhibitor* of *COX*-2, with the IC₅₀ value of 79.4 nM .

COX-2-IN-39	COX	Others
COX-2-IN-39 (compound 44) is a potent inhibitor of *COX*-2, with the IC₅₀ value of 0.4 nM .

Amfenac Sodium Hydrate	COX	Inflammation/Immunology
Amfenac Sodium Hydrate is a *COX-2* inhibitor.

HY-15762

Valdecoxib 2 Publications Verification SC 65872	COX Endogenous Metabolite	Inflammation/Immunology Cancer
Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX*-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-146198

COX-2-IN-19

COX Inflammation/Immunology

COX-2-IN-19 (Compound 24) is a potent COX-2 inhibitor with an IC₅₀ of 1.76 μM. COX-2-IN-19 shows in vivo anti-inflammatory activity .

COX-2-IN-19	COX	Inflammation/Immunology
COX-2-IN-19 (Compound 24) is a potent *COX-2* inhibitor with an IC₅₀ of 1.76 μM. COX-2-IN-19 shows in vivo anti-inflammatory activity .

HY-116947

COX-2-IN-5	COX	Inflammation/Immunology
COX-2-IN-5 (compound 11a) is a potent *COX-2* inhibitor with an IC₅₀ value of 0.65 µM. COX-2-IN-5 has the potential for the research of inflammation .

HY-161147

COX-2-IN-37	COX	Inflammation/Immunology
COX-2-IN-37 (compound 11) is a potent and selective *COX-2* inhibitor. COX-2-IN-37 has strong antioxidant activity with an IC₅₀ of 33.0 μg/mL .

HY-161266

COX-2/NLRP3-IN-1	COX NOD-like Receptor (NLR) NF-κB	Inflammation/Immunology
COX-2/NLRP3-IN-1 (Compound 6k) is a *COX-2/NLRP3* inhibitor with a IC₅₀ of 1.53 μM for COX-2. COX-2/NLRP3-IN-1 exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway .

HY-162044

COX-1/2-IN-6	COX	Inflammation/Immunology
COX-1/2-IN-6 (compound 4 h) is a potent dual inhibitor of *COX-1* and *COX-2* with IC₅₀s of 68 and 91 nM, respectively. COX-1/2-IN-6 can used in study inflammation diseases .

HY-149355

COX-2-IN-33	COX	Inflammation/Immunology
COX-2-IN-33 (compound 5f) is a *COX-2* inhibitor (IC₅₀=45.5 nM), as well as a potential anti-inflammatory agent. COX-2-IN-33 inhibits in vivo pro-inflammatory cytokine production and keep gastric safety .

HY-N0481

Roburic acid	COX	Inflammation/Immunology
Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of *COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX*-2, respectively .

HY-147809

COX-2-IN-20	COX	Inflammation/Immunology
COX-2-IN-20 (Compound 5d) is a selective and orally active *COX-2* inhibitor with an IC₅₀ of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity .

HY-N0356

(-)-Catechin gallate 1 Publications Verification (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate	COX	Cancer
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of *COX-1* and *COX-2* enzymes.

HY-B2137

S-(+)-Ketoprofen

(S)-Ketoprofen; Dexketoprofen
COX Inflammation/Immunology

S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC₅₀s of 1.9 and 27 nM, respectively.

S-(+)-Ketoprofen (S)-Ketoprofen; Dexketoprofen	COX	Inflammation/Immunology
S-(+)-Ketoprofen is a potent inhibitor of both *COX-1* and *COX-2* with IC₅₀s of 1.9 and 27 nM, respectively.

HY-115934

COX-2-IN-7	COX	Inflammation/Immunology
COX-2-IN-7 (compound 4a) is a potent, selective, and orally active inhibitor of *COX-2* with an IC₅₀ of 6.585 uM. COX-2-IN-7 has higher COX-2 selectivity than Celecoxib. COX-2-IN-7 shows good in vivo anti-inflammatory and low ulcerogenic activity .

HY-115935

COX-2-IN-8	COX	Inflammation/Immunology
COX-2-IN-8 (compound 6a) is a potent, selective, and orally active inhibitor of *COX-2* with an IC₅₀ of 6.585 uM. COX-2-IN-8 has higher COX-2 selectivity than Celecoxib. COX-2-IN-8 shows good in vivo anti-inflammatory and low ulcerogenic activity .

HY-115936

COX-2-IN-9	COX	Inflammation/Immunology
COX-2-IN-9 (compound 7a) is a potent, selective, and orally active inhibitor of *COX-2* with an IC₅₀ of 10.17 uM. COX-2-IN-9 has higher COX-2 selectivity than Celecoxib. COX-2-IN-9 shows good in vivo anti-inflammatory and low ulcerogenic activity .

HY-147794

COX-2-IN-18	COX	Cancer
COX-2-IN-18 (Compound 3) is a potent inhibitor of *COX-2. COX-2-IN-18 possesses good COX-2 inhibitory activity (IC₅₀* = 0.775 μM) compared to the reference agent, Celecoxib (IC₅₀ = 0.153 μM). COX-2-IN-18 has the potential for the research of cancer diseases .

Cat. No.	Product Name	Type

HY-14397G

Indomethacin (GMP)

Indometacin (GMP)

Biochemical Assay Reagents

Indomethacin (GMP) is Indomethacin (HY-14397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Biochemical Assay Reagents
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-14398G

Celecoxib (GMP) SC 58635 (GMP)	Biochemical Assay Reagents
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective *COX-2* inhibitor with an IC₅₀ of 40 nM.

HY-131384

8,11,14-Eicosatriynoic acid

8,11,14-Icosatriynoic acid

Biochemical Assay Reagents

8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100580

Asaraldehyde Asaronaldehyde; Asaraldehyde; 2,4,5-trimethoxy-Benzaldehyde	Acorus tatarinowii Schott Structural Classification Classification of Application Fields Araceae Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields	COX
Asarylaldehyde (Asaronaldehyde), a *COX-2* inhibitor, significantly inhibits cyclooxygenase II (COX-2) activity with an IC₅₀ value of 100 μg/mL .

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX Endogenous Metabolite
Lornoxicam (Chlortenoxicam), a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory drug (NSAID).

HY-15762

Valdecoxib 2 Publications Verification SC 65872	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX Endogenous Metabolite
Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX*-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-N0481

Roburic acid	Triterpenes Gentiana macrophylla Pall. Classification of Application Fields Terpenoids Source classification Gentianaceae Plants Disease Research Fields Inflammation/Immunology	COX
Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of *COX, with IC₅₀s of 5 and 9 μM for COX-1 and COX*-2, respectively .

HY-152120

(±)-Aiphanol Aiphanol	Structural Classification Source classification Phenols Polyphenols Arecaceae Plants Aiphanes aculeata Willd	COX VEGFR
(±)-Aiphanol is a newly discovered stilbenolignan analog. (±)-Aiphanol exhibits significant anti-inflammatory activity, acting through inhibition of *COX-1* and *COX-2. The inhibitory effect on COX-1 (IC₅₀ = 1.9 μM) is particularly strong, while the effect on COX-2 (IC₅₀= 9.9 μM) is relatively weak .(±)-Aiphanol effectively inhibits* VEGFR2 (IC₅₀=0.92 µM). (±)-Aiphanol blocks angiogenesis and promotes apoptosis through inhibition of VEGFR2 and COX2 activity. (±)-Aiphanol is orally active .

HY-N0356

(-)-Catechin gallate 1 Publications Verification (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate	Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Cancer Theaceae	COX
(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of *COX-1* and *COX-2* enzymes.

HY-N11624

Axinelline A	Structural Classification Microorganisms Source classification Phenols Polyphenols	COX
Axinelline A is a potent *COX* inhibitor with IC₅₀s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity .

HY-N11880

2-O-Sinapoyl makisterone A	Structural Classification Source classification Fibraurea recisa Pierre Plants Menispermaceae Steroids	COX
2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .

HY-15762R

Valdecoxib (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	COX Endogenous Metabolite
Valdecoxib (Standard) is the analytical standard of Valdecoxib. This product is intended for research and analytical applications. Valdecoxib is a highly potent and selective inhibitor of *COX-2, with IC₅₀s of 5 nM and 140 μM for COX-2 and COX*-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.

HY-B1227

Carprofen 2 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX FAAH Autophagy Endogenous Metabolite
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target *FAAH/COX* inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-126121

2-Hydroxy Ibuprofen (±)-2-Hydroxy Ibuprofen	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	COX
2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC₅₀s of 13 μM and 370 μM, respectively.

HY-N2599

Taraxerol acetate	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Astragalus oleifolius DC. Plants Compositae Disease Research Fields Cancer	COX Apoptosis
Taraxerol acetate is a *COX-1* and *COX-2* inhibitor with IC₅₀ values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis .

HY-N0767

Isoorientin 5 Publications Verification Homoorientin	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	COX
Isoorientin is a potent inhibitor of *COX-2* with an IC₅₀ value of 39 μM.

HY-N0929

Hexahydrocurcumin	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Curcuma longa Disease Research Fields Zingiberaceae Cancer	COX Reactive Oxygen Species
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active *COX-2* inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-N0355

(+)-Catechin hydrate 10+ Cited Publications	Flavonoids Classification of Application Fields Flavanols Source classification Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Cancer Theaceae	COX
(+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-B0367R

Lornoxicam (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	COX Endogenous Metabolite
Lornoxicam (Standard) is the analytical standard of Lornoxicam. This product is intended for research and analytical applications. Lornoxicam (Chlortenoxicam) is a highly active COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM respectively. It is a new non-steroidal anti-inflammatory compound.

HY-N0898

Catechin 10+ Cited Publications (+)-Catechin; Cianidanol; Catechuic acid	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Camellia sinensis (L.) O. Ktze. Endogenous metabolite Flavonoids Microorganisms Sunscreen Flavanols Phenols Polyphenols Cosmetic Research Disease Research Fields Cancer Theaceae	COX Apoptosis Influenza Virus Endogenous Metabolite
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM.

HY-N0147

Rutaecarpine 5 Publications Verification Rutecarpine	Alkaloids Structural Classification Classification of Application Fields Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Plants Disease Research Fields Indole Alkaloids Cancer	COX
Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor of *COX-2* with an IC₅₀ value of 0.28 μM.

HY-112731

TFAP N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	COX Endogenous Metabolite
TFAP is a selective cyclooxygenase-1 *(COX-1)* inhibitor, with an IC₅₀ of 0.8 μM.

HY-N0002

(-)-Epicatechin gallate 4 Publications Verification Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate	Flavonoids Microorganisms Classification of Application Fields Flavanols Source classification Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Cancer Theaceae	COX Autophagy Virus Protease
(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM.

HY-129113

α-Chaconine	Alkaloids Piperidine Alkaloids Zea mays L. Pyrrole Alkaloids Classification of Application Fields Gramineae Source classification Plants Disease Research Fields Inflammation/Immunology	COX
α-Chaconine inhibits the expressions of *COX-2, IL-1β, IL-6, and TNF-α* at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and *COX-2* at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .

HY-N5015

Rosmanol	Structural Classification Classification of Application Fields Brachyclados megalanthus Speg. Labiatae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	COX
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-N0389

Columbin 1 Publications Verification	other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	COX Parasite
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits *COX-2* (EC₅₀=53.1 μM) over COX-1 (EC₅₀=327 μM) .

HY-N0346A

(E)-Ethyl p-methoxycinnamate	Structural Classification Classification of Application Fields Source classification Plants Infection Kaempferia galanga L. Simple Phenylpropanols Alpinia officinarum Hance Phenylpropanoids Inflammation/Immunology Disease Research Fields Zingiberaceae Cancer	COX
(E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic and anti-microbial effects. (E)-Ethyl p-methoxycinnamate inhibits *COX-1* and *COX-2* in vitro with IC₅₀s of 1.12 and 0.83 μM, respectively .

HY-N0149

Salicin 1 Publications Verification D-(−)-Salicin; Salicoside	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Salicaceae Salix babylonica Linn.	COX Endogenous Metabolite
Salicin is a natural *COX* inhibitor.

HY-N12708

23-O-β-D-Glucopyranosyl-20-isoveratramine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Plants Melanthiaceae Veratrum oxysepalum Turcz.	Others
23-O-β-D-Glucopyranosyl-20-isoveratramine is a potential anti-allergic agent extracted from nettles. A variety of COX-1, COX-2, 5-lipoxygenase and trypsin-like inhibitors and H1 antagonists are found in nettle extract, which can inhibit seasonal allergies, allergic rhinitis and other inflammatory diseases. and preventive effects .

HY-N1380

Guaiacol 2-Methoxyphenol	Human Gut Microbiota Metabolites Monophenols other families Microorganisms Classification of Application Fields Source classification Phenols Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	COX NF-κB Endogenous Metabolite
Guaiacol, a phenolic compound, inhibits LPS-stimulated *COX-2* expression and NF-κB activation . Anti-inflammatory activity .

HY-124481

Oleocanthal	Structural Classification Monophenols Canarium album (Lour.) Rauesch. Source classification Phenols Plants Burseraceae	COX
Oleocanthal is a *COX-1/2* enzyme inhibitor and a nonsteroidal anti-inflammatory agent. Oleocanthal is obtained from virgin olive oil .

HY-N1067

Xanthohumol 5+ Cited Publications	Infection Structural Classification Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields	COX Acyltransferase Apoptosis HSV CMV Influenza Virus
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), *COX-1* and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

HY-B0167

Salicylic acid 5+ Cited Publications 2-Hydroxybenzoic acid	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Agricultural Research Monophenols other families Microorganisms Ketones, Aldehydes, Acids Phenols Phytohormone Inflammation/Immunology Disease Research Fields Cancer	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation .

HY-N0493

Pectolinarigenin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Campylotropis hirtella (Franch.) Schindl. Source classification Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	COX Lipoxygenase
Pectolinarigenin is a dual inhibitor of *COX-2/5-LOX*. Anti-inflammatory activity . Pectolinarigenin has potent inhibitory activities on melanogenesis .

HY-N7630

Rehmapicrogenin	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Inflammation/Immunology Disease Research Fields	NO Synthase COX
Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6 .

HY-N3631

Ethoxycoronarin D	Hedychium coronarium Koen. Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Inflammation/Immunology Zingiberaceae	COX
Ethoxycoronarin D is a labdane diterpenes compound isolated from rhizomes. Ethoxycoronarin D selectively inhibits COX-1 with an IC₅₀ of 3.8 µM .

HY-N3866

Esculentic acid	Triterpenes Structural Classification Terpenoids Labiatae Source classification Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	COX
Esculentic acid is a selective *COX-2* inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta .

HY-N0074

Byakangelicol 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt. Inflammation/Immunology Disease Research Fields	COX
Byakangelicol, isolated from Angelica dahurica, inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme. Byakangelicol has therapeutic potential as an anti-inflammatory agent on airway inflammation .

HY-N3848

Ermanin	Cardiovascular Disease Flavonols Structural Classification Classification of Application Fields Source classification Plants Curcuma phaeocaulis Valeton Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Zingiberaceae	Bacterial COX NO Synthase Influenza Virus
Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, *COX-2* activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties .

HY-14617

Paradol 3 Publications Verification [6]-Gingerone; [6]-Paradol	Zingiber officinale Roscoe Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer Zingiberaceae	COX
Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.

HY-N7688

Regaloside B	Monophenols Liliaceae Classification of Application Fields Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology Lilium brownie var. viridulum	NO Synthase COX
Regaloside B is a phenylpropanoid isolated from Lilium longiflorum. Regaloside B can inhibit the expression of iNOS and *COX-2*. Regaloside B has anti-inflammatory activity .

HY-N0001

(-)-Epicatechin 3 Publications Verification (-)-Epicatechol; Epicatechin; epi-Catechin	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Camellia sinensis (L.) O. Ktze. Endogenous metabolite Flavonoids Sunscreen Flavanols Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer Theaceae	COX Ferroptosis Endogenous Metabolite
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N10303

Withangulatin A	Structural Classification Cardiacglycosides Source classification Physalis angulata L. Plants Solanaceae Steroids	COX Parasite
Withangulatin A is a selective cyclooxygenase-2 (COX-2) inhibitor. Withangulatin A can be isolated from Physalis angulata L. Withangulatin A has anti-tumor, trypanocidal activity and anti-inflammatory function .

HY-N0447

8-Gingerol 1 Publications Verification	Zingiber officinale Roscoe Monophenols Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields Cancer Zingiberaceae	TRP Channel Bacterial
8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates TRPV1, with an EC₅₀ of 5.0 µM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori in vitro .

HY-N0896

Inulicin 1 Publications Verification 1-O-Acetylbritannilactone	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	NF-κB COX
Inulicin (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK. Inulicin (1-O-Acetylbritannilactone) inhibits LPS-induced PGE₂ production and *COX-2* expression, and NF-κB activation and translocation.

HY-113083

Acetaminophen glucuronide APAP-glu	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Drug Metabolite Endogenous Metabolite
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-N3632

Methoxycoronarin D Coronarin D Me ether	Hedychium coronarium Koen. Structural Classification Terpenoids Source classification Diterpenoids Plants Zingiberaceae	NF-κB COX
Methoxycoronarin D can be isolated from Hedychium coronarium J. Koenig and is a potent inhibitor of NF-魏B with an IC₅₀ value of 7.3 渭M. Methoxycoronarin D is also a selective inhibitor of *COX-1* with an IC₅₀ value of 0.9 渭M .

HY-N0396

Harpagoside 1 Publications Verification	Structural Classification Iridoids Classification of Application Fields Terpenoids Pedaliaceae Plants Inflammation/Immunology Disease Research Fields Harpagophytum procumbens	COX NO Synthase
Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on *COX-1* and *COX-2* active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ).

HY-N0002R

(-)-Epicatechin gallate (Standard) Epicatechin gallate(Standard); ECG(Standard); (-)-Epicatechin 3-O-gallate (Standard)	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Cancer Theaceae	COX Autophagy Virus Protease
(-)-Epicatechin gallate (Standard) is the analytical standard of (-)-Epicatechin gallate. This product is intended for research and analytical applications. (-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 7.5 μM.

HY-B0167A

Sodium Salicylate 5+ Cited Publications Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Asclepiadaceae Phenols Plants Periploca sepium Bunge Inflammation/Immunology Disease Research Fields Cancer	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation . Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle .

HY-N10009

Cudraflavone B	Structural Classification Brosimopsis oblongifolia Source classification Phenols Polyphenols Plants Moraceae	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of *COX-1* and *COX-2. Cudraflavone B blocks the translocation of nuclear factor κB* (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells .

HY-N6968

α-Humulene Humulene; α-Caryophyllene	Structural Classification Classification of Application Fields Source classification Myristicaceae Plants Endogenous metabolite Other Terpenoids Human Gut Microbiota Metabolites Microorganisms Terpenoids Myristica fragrans Houtt. Inflammation/Immunology Disease Research Fields	NO Synthase COX
α-Humulene is a main constituent of Tanacetum vulgare L. (Asteraceae) essential oil with anti-inflammation (IC₅₀=15±2 µg/mL). α-Humulene inhibits *COX-2* and iNOS expression .

HY-N3555

(+)-Catechin pentaacetate	Structural Classification Natural Products Source classification Taxaceae Plants Taxus wallichiana Zucc.	COX
(+)-Catechin pentaacetate is a precursor for the production of (+) catechin (HY-N0898 ). (+) catechin is a useful natural herbicide and antimicrobial. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM .

Cat. No.	Product Name	Chemical Structure

HY-B0580S

Ketorolac-d5
Ketorolac-d₅ is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1].

HY-B0808S1

Oxaprozin-d5
Oxaprozin-d₅ is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.

HY-B0008S

Sulindac-d3

Sulindac-d₃ is deuterium labeled Sulindac. Sulindac (MK-231) is a non-steroidal antiinflammatory agent, acts as a COX-2 inhibitor, and inhibits overexpression of COX-2.

HY-105028S

Tenidap-d3
Tenidap-d₃ is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor[3].

HY-B0367S

Lornoxicam-d4

Lornoxicam-d₄ is the deuterium labeled Lornoxicam. Lornoxicam (Chlortenoxicam), a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory agent (NSAID).
HY-14654S

Aspirin-d3

Aspirin-d₃ is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.
HY-78131S

Ibuprofen-d3

Ibuprofen-d₃ is a deuterium labeled Ibuprofen. Ibuprofen is a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM[1].

HY-15762S

Valdecoxib-d3
Valdecoxib-d₃ is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain[1][2].

HY-15321S

Etoricoxib-d4 1 Publications Verification
Etoricoxib-d₄ is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-B0261S1

Meloxicam-d3-1
Meloxicam-d₃-1 is the deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-B0253S

Piroxicam-d3
Piroxicam-d₃ is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively [1].

HY-15036S1

Diclofenac-13C6
Diclofenac- ¹³C₆ is the ¹³C₆ labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-15037S2

Diclofenac-13C6 sodium

Diclofenac- ¹³C₆ (Sodium) is the ¹³C₆ labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

HY-B0261S

Meloxicam-d3
Meloxicam-d₃ is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively[1].

HY-B0580S1

Ketorolac-d4
Ketorolac-d₄ (RS37619 D4) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1][2].

HY-B0253S1

Piroxicam-d4
Piroxicam-d₄ is the deuterium labeled Piroxicam. Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively.

HY-B0261S2

Meloxicam-13C,d3
Meloxicam- ¹³C,d₃ is deuterium labeled Meloxicam. Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively.

HY-14654S1

Aspirin-d4

Aspirin-d₄ is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[1][2].

HY-15037S1

Diclofenac-d4 sodium

Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-15036S

Diclofenac-d4
Diclofenac-d₄ is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-17372S

Rofecoxib-d5
Rofecoxib-d₅ is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells)[1][2].

HY-B0227S1

Ketoprofen-d4
Ketoprofen-d₄ is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-B0227S

Ketoprofen-d3
Ketoprofen-d₃ is the deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-N0356S

(+/-)-Catechin Gallate-13C3
(+/-)-Catechin Gallate- ¹³C₃ is the ¹³C-labeled (-)-Catechin gallate. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.

HY-14397S

Indomethacin-d4
Indomethacin-d₄ is a deuterium labeled Indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

HY-15037S

Diclofenac-13C6 sodium heminonahydrate

Diclofenac- ¹³C₆ (sodium heminonahydrate) is the ¹³C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

HY-B1227S

Carprofen-d3
Carprofen-d₃ is the deuterium labeled Carprofen. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-14397S1

Indomethacin-d4 Methyl Ester
Indomethacin-d₄ Methyl Ester is the deuterium labeled Indomethacin. Indomethacin (Indometacin) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin disrupts autophagic flux by disturbing the normal functioning of lysosomes[2].

HY-15321S1

Etoricoxib-13C,d3
Etoricoxib- ¹³C,d₃ is the ¹³C- and deuterium labeled Etoricoxib. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

HY-B0335S1

Tolfenamic acid-13C6
Tolfenamic acid- ¹³C₆ is the ¹³C₆ labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

HY-15321S2

Etoricoxib-d3
Etoricoxib-d₃ is the deuterium labeled Etoricoxib[1]. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood[2][3][4].

HY-B0578S

Loxoprofen-d4
Loxoprofen-d₄ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively[1][2].

HY-17357S

Nepafenac-d5

Nepafenac-d₅ is the deuterium labeled Nepafenac, which is a selective COX-2 inhibitor.

HY-B0227S2

Ketoprofen-13C,d3
Ketoprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1].

HY-B0335S

Tolfenamic Acid-D4
Tolfenamic acid-d₄ is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1[1][2].

HY-14397S2

Indometacin-d7
Indometacin-d₇ is deuterated labeled Indomethacin (HY-14397). Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

HY-14670S

Firocoxib-d4
Firocoxib-d₄ (ML 1785713-d4) is the deuterium labeled Firocoxib. Firocoxib (ML 1785713) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 0.13 μM. Firocoxib shows 58-fold more selective for COX-2 than COX-1 (IC50 of 7.5 μM). Firocoxib has anti-inflammatory effects[1].

HY-B0619S1

Zaltoprofen-13C,d3
Zaltoprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain[1][2][3].

HY-15029S2

(±)-Naproxen-13C,d3
(±)-Naproxen- ¹³C,d₃ is the deuterium and ¹³C labeled (±)-Naproxen[1]. (±)-Naproxen ((Rac)-Naproxen) is a racemate of Naproxen (HY-15030). Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively.

HY-B1227S1

Carprofen-13C,d3
Carprofen- ¹³C,d₃ is the deuterium and ¹³C labeled Carprofen[1]. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively[2][3][4].

HY-126121S

2-Hydroxy Ibuprofen-d6
2-Hydroxy Ibuprofen-d₆ is the deuterium labeled 2-Hydroxy Ibuprofen. 2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1][2].

HY-78131AS

(S)-(+)-Ibuprofen D3
(S)-(+)-Ibuprofen-d₃ is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].

HY-B1888AS

Bromfenac-d4 sodium

Bromfenac-d₄ (sodium) is deuterium labeled Bromfenac (sodium). Bromfenac sodium is a potent and orally active inhibitor of COX, with IC50s of 5.56 and 7.45 nM for COX-1 and COX-2, respectively. Bromfenac sodium is a brominated non-steroidal anti-inflammatory/analgesic agent (NSAID), and it is commonly used for the research of postoperative inflammation and pain following cataract surgery, and pseudophakic cystoid macular edema (CME)[1][2].

HY-B0363S

Nimesulide D5
Nimesulide-d₅ is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties[1][2].

HY-N0898S

Catechin-13C3

Catechin- ¹³C₃ is the ¹³C-labeled Catechin. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.

HY-14398S1

Celecoxib-d3
Celecoxib-d₃ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

HY-14398S

Celecoxib-d7
Celecoxib-d₇ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM[1][2].

HY-B0167S

Salicylic acid-d6
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-B0559S

Nabumetone-d3
Nabumetone-d₃ is the deuterium labeled Nabumetone. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.

HY-N1380S1

Guaiacol-d3
Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1].

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