Diclofenac-d₄ sodium

Name: Diclofenac-d 4 sodium
Brand: MedChemExpress
SKU: HY-15037S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-15037S1 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Diclofenac-d₄ (sodium) is the deuterium labeled Diclofenac sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

For research use only. We do not sell to patients.

Diclofenac-d<sub>4</sub> sodium Chemical Structure

Diclofenac-d₄ sodium Chemical Structure

CAS No. : 154523-54-3

Size	Price	Stock	Quantity
1 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Diclofenac-d₄ sodium:

Diclofenac Sodium In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

322.16

Formula

C₁₄H₆D₄Cl₂NNaO₂

CAS No.

154523-54-3

Unlabeled CAS

15307-79-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CC(C([2H])=C([2H])C([2H])=C1[2H])=C1NC2=C(C=CC=C2Cl)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H2O : 10 mg/mL (31.04 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1040 mL	15.5202 mL	31.0405 mL
5 mM	0.6208 mL	3.1040 mL	6.2081 mL
10 mM	0.3104 mL	1.5520 mL	3.1040 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (256 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [Content Brief]

[3]. Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80. [Content Brief]

[4]. Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	3.1040 mL	15.5202 mL	31.0405 mL	77.6012 mL
	5 mM	0.6208 mL	3.1040 mL	6.2081 mL	15.5202 mL
	10 mM	0.3104 mL	1.5520 mL	3.1040 mL	7.7601 mL
	15 mM	0.2069 mL	1.0347 mL	2.0694 mL	5.1734 mL
	20 mM	0.1552 mL	0.7760 mL	1.5520 mL	3.8801 mL
	25 mM	0.1242 mL	0.6208 mL	1.2416 mL	3.1040 mL
	30 mM	0.1035 mL	0.5173 mL	1.0347 mL	2.5867 mL