α-Vitamin E-d₆ (Synonyms: (+)-α-Tocopherol-d₆; D-α-Tocopherol-d₆)

Cat. No.: HY-N7148S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

α-Vitamin E-d₆ is the deuterium labeled α-Vitamin E[1].

For research use only. We do not sell to patients.

α-Vitamin E-d<sub>6</sub> Chemical Structure

α-Vitamin E-d₆ Chemical Structure

CAS No. : 113892-08-3

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1 mg		Check price and availability

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This product is a controlled substance and not for sale in your territory.

Other Forms of α-Vitamin E-d₆:

γ-Tocopherol In-stock

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Biological Activity
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References
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Description

α-Vitamin E-d₆ is the deuterium labeled α-Vitamin E[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

436.74

Formula

C₂₉H₄₄D₆O₂

CAS No.

113892-08-3

Unlabeled CAS

59-02-9

Appearance

Oil

Color

Light yellow to yellow

SMILES

OC1=C(C([2H])([2H])[2H])C(C)=C2C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O2)=C1C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (228.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2897 mL	11.4485 mL	22.8969 mL
5 mM	0.4579 mL	2.2897 mL	4.5794 mL
10 mM	0.2290 mL	1.1448 mL	2.2897 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (244 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2897 mL	11.4485 mL	22.8969 mL	57.2423 mL
	5 mM	0.4579 mL	2.2897 mL	4.5794 mL	11.4485 mL
	10 mM	0.2290 mL	1.1448 mL	2.2897 mL	5.7242 mL
	15 mM	0.1526 mL	0.7632 mL	1.5265 mL	3.8162 mL
	20 mM	0.1145 mL	0.5724 mL	1.1448 mL	2.8621 mL
	25 mM	0.0916 mL	0.4579 mL	0.9159 mL	2.2897 mL
	30 mM	0.0763 mL	0.3816 mL	0.7632 mL	1.9081 mL
	40 mM	0.0572 mL	0.2862 mL	0.5724 mL	1.4311 mL
	50 mM	0.0458 mL	0.2290 mL	0.4579 mL	1.1448 mL
	60 mM	0.0382 mL	0.1908 mL	0.3816 mL	0.9540 mL
	80 mM	0.0286 mL	0.1431 mL	0.2862 mL	0.7155 mL
	100 mM	0.0229 mL	0.1145 mL	0.2290 mL	0.5724 mL

α-Vitamin E-d₆ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Vitamin E-d₆113892-08-3(+)-α-Tocopherol-d₆D-α-Tocopherol-d₆Endogenous MetaboliteIsotope-Labeled CompoundsCOXCyclooxygenaseInhibitorinhibitorinhibit

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α-Vitamin E-d6 (Synonyms: (+)-α-Tocopherol-d6; D-α-Tocopherol-d6)

Other Forms of α-Vitamin E-d6:

α-Vitamin E-d6 Related Antibodies