2. Immunology/Inflammation
  3. PGE synthase
  4. UK4b

UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice.

For research use only. We do not sell to patients.

UK4b Chemical Structure

UK4b Chemical Structure

CAS No. : 2171000-87-4

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UK4b Related Antibodies

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Description

UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice[1].

In Vivo

UK4b (10-20 mg/kg; s.c.; twice daily for 22 consecutive days) can block the further growth of abdominal aortic aneurysms (AAA) in an ApoE−/− angiotensin (Ang) II (1000 ng/kg/min; infusion for 28 consecutive days) -induced mouse model of AAA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

404.89

Formula

C21H25ClN2O4
CAS No.
SMILES

ClC(C=C(/C=C1C(NC(NC/1=O)=O)=O)C=C2)=C2OCCCCC3CCCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UK4b Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UK4b2171000-87-4PGE synthaseProstaglandin E synthaseAbdominal aortic aneurysm (AAA)anti-inflammatoryease painInhibitorinhibitorinhibit

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