Tunicamycin V  (Synonyms: Tunicamycin A)

Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC₅₀ of 0.35 μM. Tunicamycin V has antibacterial activties^[1][2].

IC50: 0.35 μM (phospho-N-acetylmuramyl-pentapeptide transferase (MraY))^[1]

Tunicamycins are nucleoside natural products isolated from the fermentation broths of Streptomyces lysosuperficus in 1971 and exhibit a variety of biological properties including antibacterial, antiviral, antifungal, and antitumor activities. Tunicamycins strongly inhibit UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase, the enzyme responsible for the first N-acetylglucosamination of the N-linked glycopeptide in endothelial reticulum (ER)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

844.94

C₃₉H₆₄N₄O₁₆

66054-36-2

Solid

White to off-white

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Room temperature in continental US; may vary elsewhere.

• [1]. Kazuki Yamamoto, et al. Structural requirement of tunicamycin V for MraY inhibition. Bioorg Med Chem. 2019 Apr 15;27(8):1714-1719.  [Content Brief]

  [2]. Kazuki Yamamoto, et al. Total Synthesis of Tunicamycin V. Org Lett. 2018 Jan 5;20(1):256-259.  [Content Brief]