Trimethylamine N-oxide-d₉

Name: Trimethylamine N-oxide-d 9
Brand: MedChemExpress
SKU: HY-116084S
Rating: 4.5 (1 reviews)

Cat. No.: HY-116084S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].

For research use only. We do not sell to patients.

Trimethylamine N-oxide-d<sub>9</sub> Chemical Structure

Trimethylamine N-oxide-d₉ Chemical Structure

CAS No. : 1161070-49-0

Size	Price	Stock	Quantity
1 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Trimethylamine N-oxide-d₉:

Trimethylamine N-oxide dihydrate In-stock
Trimethylamine N-oxide In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

84.17

Formula

C₃D₉NO

CAS No.

1161070-49-0

Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([N+](C([2H])([2H])[2H])([O-])C([2H])([2H])[2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H2O : 100 mg/mL (1188.07 mM; Need ultrasonic)

DMSO : 100 mg/mL (1188.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	11.8807 mL	59.4036 mL	118.8072 mL
5 mM	2.3761 mL	11.8807 mL	23.7614 mL
10 mM	1.1881 mL	5.9404 mL	11.8807 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (280 KB) SDS (392 KB)

COA (257 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Wei Shuai, et al. High-choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. J Card Fail. 2020 May 14;S1071-9164(19)31802-0. [Content Brief]

[3]. Wenlong Yang, et al. Gut Microbe-Derived Metabolite Trimethylamine N-oxide Accelerates Fibroblast-Myofibroblast Differentiation and Induces Cardiac Fibrosis. J Mol Cell Cardiol. 2019 Sep;134:119-130. [Content Brief]

[4]. Manuel T Velasquez, et al. Trimethylamine N-Oxide: The Good, the Bad and the Unknown. Toxins (Basel). 2016 Nov 8;8(11):326. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O / DMSO	1 mM	11.8807 mL	59.4036 mL	118.8072 mL	297.0179 mL
	5 mM	2.3761 mL	11.8807 mL	23.7614 mL	59.4036 mL
	10 mM	1.1881 mL	5.9404 mL	11.8807 mL	29.7018 mL
	15 mM	0.7920 mL	3.9602 mL	7.9205 mL	19.8012 mL
	20 mM	0.5940 mL	2.9702 mL	5.9404 mL	14.8509 mL
	25 mM	0.4752 mL	2.3761 mL	4.7523 mL	11.8807 mL
	30 mM	0.3960 mL	1.9801 mL	3.9602 mL	9.9006 mL
	40 mM	0.2970 mL	1.4851 mL	2.9702 mL	7.4254 mL
	50 mM	0.2376 mL	1.1881 mL	2.3761 mL	5.9404 mL
	60 mM	0.1980 mL	0.9901 mL	1.9801 mL	4.9503 mL
	80 mM	0.1485 mL	0.7425 mL	1.4851 mL	3.7127 mL
	100 mM	0.1188 mL	0.5940 mL	1.1881 mL	2.9702 mL