2. Others Anti-infection Autophagy
  3. Isotope-Labeled Compounds Bacterial HIV Autophagy
  4. Tizoxanide-d4

Tizoxanide-d4 is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities[1][2].

For research use only. We do not sell to patients.

Tizoxanide-d<sub>4</sub> Chemical Structure

Tizoxanide-d4 Chemical Structure

CAS No. : 1246817-56-0

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1 mg USD 190 In-stock
5 mg USD 680 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Tizoxanide-d4:

Tizoxanide-d4 Related Antibodies

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Description

Tizoxanide-d4 is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tizoxanide-d4 Related Antibodies
Molecular Weight

269.27

Formula

C10H3D4N3O4S
CAS No.
Unlabeled CAS

173903-47-4
Appearance

Solid

Color

White to off-white

SMILES

O=[N+]([O-])C1=CN=C(S1)NC(C2=C(C([2H])=C([2H])C([2H])=C2[2H])O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (92.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 1 mg/mL (3.71 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7137 mL 18.5687 mL 37.1374 mL
5 mM 0.7427 mL 3.7137 mL 7.4275 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 3.7137 mL 18.5687 mL 37.1374 mL 92.8436 mL
DMSO 5 mM 0.7427 mL 3.7137 mL 7.4275 mL 18.5687 mL
10 mM 0.3714 mL 1.8569 mL 3.7137 mL 9.2844 mL
15 mM 0.2476 mL 1.2379 mL 2.4758 mL 6.1896 mL
20 mM 0.1857 mL 0.9284 mL 1.8569 mL 4.6422 mL
25 mM 0.1485 mL 0.7427 mL 1.4855 mL 3.7137 mL
30 mM 0.1238 mL 0.6190 mL 1.2379 mL 3.0948 mL
40 mM 0.0928 mL 0.4642 mL 0.9284 mL 2.3211 mL
50 mM 0.0743 mL 0.3714 mL 0.7427 mL 1.8569 mL
60 mM 0.0619 mL 0.3095 mL 0.6190 mL 1.5474 mL
80 mM 0.0464 mL 0.2321 mL 0.4642 mL 1.1605 mL
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Tizoxanide-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tizoxanide-d41246817-56-0Isotope-Labeled CompoundsBacterialHIVAutophagyHuman immunodeficiency virusInhibitorinhibitorinhibit

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