TbPTR1 inhibitor 2

Cat. No.: HY-W009689: FAQs
Data Sheet Handling Instructions

Molarity Calculator

TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC₅₀s of 34.2 and 32.9 μM for TbPTR1 and LmPTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei (IC₅₀: 34.2 μM).

For research use only. We do not sell to patients.

TbPTR1 inhibitor 2 Chemical Structure

CAS No. : 17557-67-4

Size	Price	Stock	Quantity
5 mg	USD 48	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

228.29

Formula

C₈H₈N₂O₂S₂

CAS No.

17557-67-4

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC2=CC=C(S(=O)(C)=O)C=C2S1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (547.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3804 mL	21.9020 mL	43.8039 mL
5 mM	0.8761 mL	4.3804 mL	8.7608 mL
10 mM	0.4380 mL	2.1902 mL	4.3804 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Linciano P, et al. Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. J Med Chem. 2019 Apr 25;62(8):3989-4012. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.3804 mL	21.9020 mL	43.8039 mL	109.5098 mL
	5 mM	0.8761 mL	4.3804 mL	8.7608 mL	21.9020 mL
	10 mM	0.4380 mL	2.1902 mL	4.3804 mL	10.9510 mL
	15 mM	0.2920 mL	1.4601 mL	2.9203 mL	7.3007 mL
	20 mM	0.2190 mL	1.0951 mL	2.1902 mL	5.4755 mL
	25 mM	0.1752 mL	0.8761 mL	1.7522 mL	4.3804 mL
	30 mM	0.1460 mL	0.7301 mL	1.4601 mL	3.6503 mL
	40 mM	0.1095 mL	0.5475 mL	1.0951 mL	2.7377 mL
	50 mM	0.0876 mL	0.4380 mL	0.8761 mL	2.1902 mL
	60 mM	0.0730 mL	0.3650 mL	0.7301 mL	1.8252 mL
	80 mM	0.0548 mL	0.2738 mL	0.5475 mL	1.3689 mL
	100 mM	0.0438 mL	0.2190 mL	0.4380 mL	1.0951 mL