2. Cell Cycle/DNA Damage Others Epigenetics
  3. HDAC Isotope-Labeled Compounds
  4. Tasquinimod-d3

Tasquinimod-d3  (Synonyms: ABR-215050-d3)

Cat. No.: HY-10528S Purity: 99.34%
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Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor.

For research use only. We do not sell to patients.

Tasquinimod-d<sub>3</sub> Chemical Structure

Tasquinimod-d3 Chemical Structure

CAS No. : 1416701-99-9

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1 mg USD 200 In-stock
5 mg USD 520 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor[1][2][3].

Molecular Weight

409.37

Formula

C20H14D3F3N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=CC=C(C=C1)C(F)(F)F)C([2H])([2H])[2H])C2=C(C3=C(C=CC=C3OC)N(C2=O)C)O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (244.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4428 mL 12.2139 mL 24.4278 mL
5 mM 0.4886 mL 2.4428 mL 4.8856 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4428 mL 12.2139 mL 24.4278 mL 61.0694 mL
5 mM 0.4886 mL 2.4428 mL 4.8856 mL 12.2139 mL
10 mM 0.2443 mL 1.2214 mL 2.4428 mL 6.1069 mL
15 mM 0.1629 mL 0.8143 mL 1.6285 mL 4.0713 mL
20 mM 0.1221 mL 0.6107 mL 1.2214 mL 3.0535 mL
25 mM 0.0977 mL 0.4886 mL 0.9771 mL 2.4428 mL
30 mM 0.0814 mL 0.4071 mL 0.8143 mL 2.0356 mL
40 mM 0.0611 mL 0.3053 mL 0.6107 mL 1.5267 mL
50 mM 0.0489 mL 0.2443 mL 0.4886 mL 1.2214 mL
60 mM 0.0407 mL 0.2036 mL 0.4071 mL 1.0178 mL
80 mM 0.0305 mL 0.1527 mL 0.3053 mL 0.7634 mL
100 mM 0.0244 mL 0.1221 mL 0.2443 mL 0.6107 mL
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Tasquinimod-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tasquinimod-d31416701-99-9ABR-215050-d3HDACIsotope-Labeled CompoundsHistone deacetylasesstable isotopesInhibitorinhibitorinhibit

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