1. Others Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Autophagy
  2. Isotope-Labeled Compounds Mineralocorticoid Receptor Androgen Receptor Autophagy
  3. Spironolactone-d3-1

Spironolactone-d3-1  (Synonyms: SC9420-d3-1)

Cat. No.: HY-B0561S2
Handling Instructions

Spironolactone-d3-1 is deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

For research use only. We do not sell to patients.

Spironolactone-d<sub>3</sub>-1 Chemical Structure

Spironolactone-d3-1 Chemical Structure

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Description

Spironolactone-d3-1 is deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

419.59

Formula

C24H29D3O4S

Unlabeled CAS

52-01-7

SMILES

C[C@@]12[C@](OC3=O)(CC3)CC[C@@]1([H])[C@@]([C@@H](CC4=C([2H])C5=O)SC(C)=O)([H])[C@]([C@]4(CC5([2H])[2H])C)([H])CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Spironolactone-d3-1
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