2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3

SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 

Cat. No.: HY-153962 Purity: 95.08%
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SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a Drug-Linker Conjugate for ADC. SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 consists of the anti-cancer agent SN38 (HY-13704) and a linker Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 (HY-131157). SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 can be used for synthesis of ADCs. SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 Chemical Structure

SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 Chemical Structure

CAS No. : 1373170-36-5

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1 mg USD 880 In-stock
5 mg USD 2000 In-stock
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SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 Related Antibodies

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Description

SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a Drug-Linker Conjugate for ADC. SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 consists of the anti-cancer agent SN38 (HY-13704) and a linker Lys(MMT)-PAB-oxydiacetamide-PEG8-N3 (HY-131157). SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 can be used for synthesis of ADCs[1]. SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Molecular Weight

1478.64

Formula

C78H95N9O20
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1[C@](OC(OCC2=CC=C(NC([C@@H](NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)CCCCNC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=C(OC)C=C5)=O)C=C2)=O)(CC)C6=C(CO1)C(N7CC8=C(CC)C9=CC(O)=CC=C9N=C8C7=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (67.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6763 mL 3.3815 mL 6.7630 mL
5 mM 0.1353 mL 0.6763 mL 1.3526 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6763 mL 3.3815 mL 6.7630 mL 16.9074 mL
5 mM 0.1353 mL 0.6763 mL 1.3526 mL 3.3815 mL
10 mM 0.0676 mL 0.3381 mL 0.6763 mL 1.6907 mL
15 mM 0.0451 mL 0.2254 mL 0.4509 mL 1.1272 mL
20 mM 0.0338 mL 0.1691 mL 0.3381 mL 0.8454 mL
25 mM 0.0271 mL 0.1353 mL 0.2705 mL 0.6763 mL
30 mM 0.0225 mL 0.1127 mL 0.2254 mL 0.5636 mL
40 mM 0.0169 mL 0.0845 mL 0.1691 mL 0.4227 mL
50 mM 0.0135 mL 0.0676 mL 0.1353 mL 0.3381 mL
60 mM 0.0113 mL 0.0564 mL 0.1127 mL 0.2818 mL
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SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SN38-PAB-Lys(MMT)-oxydiacetamide-PEG8-N31373170-36-5Drug-Linker Conjugates for ADCADCsanti-cancerPEG8SN38Inhibitorinhibitorinhibit

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