2. Apoptosis
  3. Apoptosis
  4. SLC7A11-IN-1

SLC7A11-IN-1 is a potent solute carrier family 7 member 11 (SLC7A11, xCT) inhibitor. SLC7A11-IN-1 shows antiproliferative activity. SLC7A11-IN-1 inhibits cell invasion and metastasis. SLC7A11-IN-1 induces Apoptosis and cell cycle arrest at S-phase. SLC7A11-IN-1 shows anti-tumor activity.

For research use only. We do not sell to patients.

SLC7A11-IN-1 Chemical Structure

SLC7A11-IN-1 Chemical Structure

Size Price Stock Quantity
5 mg USD 870 In-stock
10 mg USD 1180 In-stock
25 mg USD 1980 In-stock
50 mg USD 2980 In-stock
100 mg USD 4380 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

SLC7A11-IN-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SLC7A11-IN-1 is a potent solute carrier family 7 member 11 (SLC7A11, xCT) inhibitor. SLC7A11-IN-1 shows antiproliferative activity. SLC7A11-IN-1 inhibits cell invasion and metastasis. SLC7A11-IN-1 induces Apoptosis and cell cycle arrest at S-phase. SLC7A11-IN-1 shows anti-tumor activity[1].

IC50 & Target

SLC7A11[1]
In Vitro

SLC7A11-IN-1 (compound 2; 0-100 µM; 72 h) shows antiproliferative activity with IC50s of 0.03, 0.11, 0.18, 0.17, 0.27 µM for HCT-116, MDA-MB-231, MCF-7, HepG2, LO2 cells, respectively[1].
SLC7A11-IN-1 (0.5 µM; 24 h) inhibits invasion and metastasis of HCT-116 cells[1].
SLC7A11-IN-1 (0.5 µM; 24 h) induces cell apoptosis and cell cycle arrest at S-phase[1].
SLC7A11-IN-1 obviously reduces the intracellular GSH content and significantly enhances reactive oxygen species (ROS) expression[1].
SLC7A11-IN-1 (1 µM; 15 h) significantly induced DNA damage and related proteins expression in HCT-116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SLC7A11-IN-1 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.5 µM
Incubation Time: 24 h
Result: Induced cell apoptosis and cell cycle arrest at S-phase with the S-phase proportion of 55.79%.

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 1 µM
Incubation Time: 15 h
Result: Increased the expression of p53, Bax, p-Akt, VEGFA and HIF1-α proteins, decreased the expression of Bcl-2, xCT protein level.
In Vivo

SLC7A11-IN-1 (2 mg/kg; i.v.; every three days for consecutive 3 times) inhibits the growth of tumors in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male BALB/c mice (CT26 tumor models)[1]
Dosage: 2 mg/kg
Administration: I.v.; once every three days, for consecutive 3 times
Result: Suppressed the growth of tumor by 60.7%.
Molecular Weight

662.33

Formula

C13H15Cl2F3N4O5PtS
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

N[Pt](O)(Cl)(Cl)(OC(CCCC(NC1=NC2=CC=C(C=C2S1)OC(F)(F)F)=O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (30.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5098 mL 7.5491 mL 15.0982 mL
5 mM 0.3020 mL 1.5098 mL 3.0196 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 95.93%

COA (258 KB) HNMR (123 KB) RP-HPLC (141 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5098 mL 7.5491 mL 15.0982 mL 37.7455 mL
5 mM 0.3020 mL 1.5098 mL 3.0196 mL 7.5491 mL
10 mM 0.1510 mL 0.7549 mL 1.5098 mL 3.7746 mL
15 mM 0.1007 mL 0.5033 mL 1.0065 mL 2.5164 mL
20 mM 0.0755 mL 0.3775 mL 0.7549 mL 1.8873 mL
25 mM 0.0604 mL 0.3020 mL 0.6039 mL 1.5098 mL
30 mM 0.0503 mL 0.2516 mL 0.5033 mL 1.2582 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SLC7A11-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLC7A11-IN-1ApoptosisHCT-116 cellsantiproliferativeinvasionmetastasiGSHROSapoptosisanti-tumorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SLC7A11-IN-1
Cat. No.:
HY-149979
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.