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Pathways Recommended: Membrane Transporter/Ion Channel
Results for "

membrane localization

" in MedChemExpress (MCE) Product Catalog:

76

Inhibitors & Agonists

1

Screening Libraries

13

Fluorescent Dye

1

Biochemical Assay Reagents

3

Peptides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1105
    GaTx2

    		Chloride Channel Neurological Disease
    GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in determining the role and the membrane localization of ClC-2 in specific cell types .
    GaTx2
  • HY-128350A
    FGTI-2734 mesylate

    		Farnesyl Transferase Cancer
    FGTI-2734 mesylate is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. FGTI-2734 mesylate can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .
    FGTI-2734 mesylate
  • HY-128350
    FGTI-2734

    		Farnesyl Transferase Cancer
    FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT-1, respectively. FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors .
    FGTI-2734
  • HY-149709
    ICMT-IN-35

    		ICMT Cancer
    ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 μM). ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT +/+ MEF cells and has low micromolar activity (IC50=0.8 μM) against metastatic pancreatic cancer cell lines .
    ICMT-IN-35
  • HY-149710
    POP-3MB

    		ICMT ERK Cancer
    POP-3MB (compound 1b) is an ICMT inhibitor (IC50: 2.5 μM). POP-3MB changes the subcellular localization of K-Ras and inhibits Ras activation. POP-3MB also inhibits Erk phosphorylation .
    POP-3MB
  • HY-D0986
    TMA-DPH
    5+ Cited Publications

    		 Fluorescent Dye Others
    TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined .
    TMA-DPH
  • HY-D1585
    BODIPY TR methyl ester

    		Fluorescent Dye Others
    BODIPY TR methyl ester is a lipophilic GFP Counterstain. BODIPY TR methyl ester dye readily permeates cell membranes and localizes in endomembranous organelles but not localize strongly in plasma membranes. BODIPY TR methyl ester is an excellent red fluorescent vital dye (Ex=568 nm, Em=625 nm), can be used to reveal the location and shapes of cell nuclei, the shapes of cells within embryonic tissues, as well as the bound aries of organ-forming tissues within the whole embryo .
    BODIPY TR methyl ester
  • HY-P10364
    Ubiquicidin(29-41)

    UBI(29-41)

    		 Bacterial Antibiotic Inflammation/Immunology
    Ubiquicidin(29-41) is a antimicrobial peptide highly homologous to S30. Ubiquicidin(29-41) targets bacterial and fungal cell. Ubiquicidin(29-41) can be used as a membrane specific infection localizer .
    Ubiquicidin(29-41)
  • HY-D2263
    BODIPY-cholesterol conjugate-3

    		Fluorescent Dye Others
    BODIPY-cholesterol conjugate-3 (compound 7) is a cholesterol analogue with a fluorescent BODIPY group. BODIPY-cholesterol conjugate-3 can be used to simultaneously visualize multiple cholesterol pools in cells, as it is primarily localized to the plasma membrane .
    BODIPY-cholesterol conjugate-3
  • HY-D2301
    mgc(3Me)FL

    		Fluorescent Dye Others
    mgc(3Me)FL is the active fluorescent form of mgc(3Me)FDA (HY-D2300) after hydrolysis in cells. mgc(3Me)FL subcellularly localizes to the Golgi apparatus and is a visualized Golgi probe. mgc(3Me)FL also binds to the outer leaflet of the plasma membrane (PM), causing the plasma membrane to fluoresce .
    mgc(3Me)FL
  • HY-163462
    Poacic acid

    		Fungal Infection
    Poacic Acid is a plant-derived stilbenoid with an antifungal activity. Poacic Acid localizes to the yeast cell wall and disrupts the production and assembly of β-1,3-glucan in the fungal cell walls. Poacic Acid exhibits fungicidal activity to Saccharomyces cerevisiae and plasma membrane-compromised Candida albicans mutants .
    Poacic acid
  • HY-130533
    ReAsH-EDT2

    		Fluorescent Dye Others
    ReAsH-EDT2 is a red fluorescent dye that marks proteins. ReAsH-EDT2 is a membrane-permeable biarsenical compound that binds covalently to tetracysteine sequences which allows the protein to be imaged. ReAsH-EDT2 can be used for protein localization and trafficking. (λex=530 nm, λem=592 nm) .
    ReAsH-EDT2
  • HY-D0079
    Dihydroethidium
    Maximum Cited Publications
    53 Publications Verification

    Hydroethidine; PD-MY 003

    		 Fluorescent Dye Others
    Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .
    Dihydroethidium
  • HY-D1106
    Py-BODIPY-NHS ester

    		Fluorescent Dye Cancer
    BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions . Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells .
    Py-BODIPY-NHS ester
  • HY-D1237
    BODIPY 505/515
    1 Publications Verification

    		 Fluorescent Dye Metabolic Disease
    BODIPY505/515 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 505/515 nm .
    BODIPY 505/515
  • HY-D1570
    BODIPY FL C12

    		Fluorescent Dye Others
    BODIPYFL C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 480/508 nm .
    BODIPY FL C12
  • HY-W090090
    BODIPY 493/503
    10+ Cited Publications

    Pyrromethene 546; BDP 493/503 lipid stain

    		 Fluorescent Dye Others
    BODIPY493/503 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .
    BODIPY 493/503
  • HY-138226
    BODIPY 558/568 C12

    		Fluorescent Dye Others
    BODIPY 558/568 C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 558/568 nm .
    BODIPY 558/568 C12
  • HY-D1614
    BODIPY 493/503 methyl bromide
    4 Publications Verification

    		 Fluorescent Dye Others
    BODIPY493/503 methyl bromide is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .
    BODIPY 493/503 methyl bromide
  • HY-D1617
    BODIPY 500/510 C1, C12

    		Fluorescent Dye Others
    BODIPY 500/510 C1, C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 500/510 nm . Protect from light, stored at -20℃.
    BODIPY 500/510 C1, C12
  • HY-157092B
    (R)-ICMT-IN-3

    		ICMT Cancer
    (R)-ICMT-IN-3 (compound ent 2-27) is an inhibitor of ICMT (IC50=0.01 μM) .
    (R)-ICMT-IN-3
  • HY-157092A
    (S)-ICMT-IN-3

    		ICMT Cancer
    (S)-ICMT-IN-3 (compound ent 1-27) is an inhibitor of ICMT (IC50=0.23 μM) .
    (S)-ICMT-IN-3
  • HY-156500
    ICMT-IN-1

    		ICMT Cancer
    ICMT-IN-1 (compound 75) is an inhibitor of ICMT (IC50=0.0013 μM). ICMT-IN-1 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras .
    ICMT-IN-1
  • HY-157097
    ICMT-IN-10

    		ICMT Cancer
    ICMT-IN-10 (compound 32) is an inhibitor of ICMT (IC50=0.184 μM) .
    ICMT-IN-10
  • HY-155421
    ICMT-IN-11

    		ICMT Cancer
    ICMT-IN-11 (compound 48) is an inhibitor of ICMT (IC50=0.031 μM) .
    ICMT-IN-11
  • HY-149706
    ICMT-IN-12

    		ICMT Cancer
    ICMT-IN-12 (compound 78) is an inhibitor of ICMT (IC50=0.42 μM) .
    ICMT-IN-12
  • HY-155422
    ICMT-IN-13

    		ICMT Cancer
    ICMT-IN-13 (compound 49) is an inhibitor of ICMT (IC50=0.47 μM) .
    ICMT-IN-13
  • HY-155423
    ICMT-IN-14

    		ICMT Cancer
    ICMT-IN-14 (compound 50) is an inhibitor of ICMT (IC50=0.025 μM) .
    ICMT-IN-14
  • HY-155424
    ICMT-IN-15

    		ICMT Cancer
    ICMT-IN-15 (compound 51) is an inhibitor of ICMT (IC50=0.032 μM) .
    ICMT-IN-15
  • HY-157098
    ICMT-IN-16

    		ICMT Cancer
    ICMT-IN-16 (compound 33) is an inhibitor of ICMT (IC50=0.131 μM) .
    ICMT-IN-16
  • HY-155425
    ICMT-IN-17

    		ICMT Cancer
    ICMT-IN-17 (compound 52) is an inhibitor of ICMT (IC50=0.38 μM) .
    ICMT-IN-17
  • HY-157099
    ICMT-IN-18

    		ICMT Cancer
    ICMT-IN-18 (compound 35) is an inhibitor of ICMT (IC50=0.066 μM) .
    ICMT-IN-18
  • HY-155426
    ICMT-IN-19

    		ICMT Cancer
    ICMT-IN-19 (compound 53) is an inhibitor of ICMT (IC50=0.026 μM) .
    ICMT-IN-19
  • HY-155418
    ICMT-IN-2

    		ICMT Cancer
    ICMT-IN-2 (compound 45) is an inhibitor of ICMT (IC50=0.168 μM) .
    ICMT-IN-2
  • HY-155427
    ICMT-IN-20

    		ICMT Cancer
    ICMT-IN-20 (compound 54) is an inhibitor of ICMT (IC50=0.682 μM) .
    ICMT-IN-20
  • HY-149707
    ICMT-IN-21

    		ICMT Cancer
    ICMT-IN-21 (compound 6ag) is an ICMT inhibitor (IC50=8.8 μM), a sulfonamide-modified farnesyl cysteine (SMFC). The farnesyl and carboxylic acid motifs of ICMT-IN-21 are important structures for inhibiting ICMT .
    ICMT-IN-21
  • HY-155428
    ICMT-IN-22

    		ICMT Cancer
    ICMT-IN-22 (compound 62) is an inhibitor of ICMT (IC50=0.63 μM) .
    ICMT-IN-22
  • HY-157100
    ICMT-IN-23

    		ICMT Cancer
    ICMT-IN-23 (compound 36) is an inhibitor of ICMT (IC50=0.123 μM) .
    ICMT-IN-23
  • HY-155429
    ICMT-IN-24

    		ICMT Cancer
    ICMT-IN-24 (compound 63) is an inhibitor of ICMT (IC50=0.19 μM) .
    ICMT-IN-24
  • HY-157101
    ICMT-IN-25

    		ICMT Cancer
    ICMT-IN-25 (compound 37) is an inhibitor of ICMT (IC50=0.025 μM) .
    ICMT-IN-25
  • HY-157102
    ICMT-IN-26

    		ICMT Cancer
    ICMT-IN-26 (compound 38) is an inhibitor of ICMT (IC50=0.36 μM) .
    ICMT-IN-26
  • HY-155430
    ICMT-IN-27

    		ICMT Cancer
    ICMT-IN-27 (compound 64) is an inhibitor of ICMT (IC50=0.1 μM) .
    ICMT-IN-27
  • HY-155431
    ICMT-IN-28

    		ICMT Cancer
    ICMT-IN-28 (compound 65) is an inhibitor of ICMT (IC50=0.008 μM) .
    ICMT-IN-28
  • HY-155432
    ICMT-IN-29

    		ICMT Cancer
    ICMT-IN-29 (compound 66) is an inhibitor of ICMT (IC50=0.019 μM) .
    ICMT-IN-29
  • HY-157092
    ICMT-IN-3

    		ICMT Cancer
    ICMT-IN-3 (compound 27) is an inhibitor of ICMT (IC50=0.015 μM) .
    ICMT-IN-3
  • HY-155433
    ICMT-IN-30

    		ICMT Cancer
    ICMT-IN-30 (compound 67) is an inhibitor of ICMT (IC50=0.27 μM) .
    ICMT-IN-30
  • HY-155434
    ICMT-IN-31

    		ICMT Cancer
    ICMT-IN-31 (compound 68) is an inhibitor of ICMT (IC50=0.0038 μM) .
    ICMT-IN-31
  • HY-155435
    ICMT-IN-32

    		ICMT Cancer
    ICMT-IN-32 (compound 70) is an inhibitor of ICMT (IC50=0.777 μM) .
    ICMT-IN-32
  • HY-155436
    ICMT-IN-33

    		ICMT Cancer
    ICMT-IN-33 (compound 73) is an inhibitor of ICMT (IC50=0.46 μM) .
    ICMT-IN-33
  • HY-157103
    ICMT-IN-34

    		ICMT Cancer
    ICMT-IN-34 (compound 39) is an inhibitor of ICMT (IC50=0.17 μM) .
    ICMT-IN-34

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