hepatoma carcinoma

By Targets:	Apoptosis (1) Pyroptosis (1) Toll-like Receptor (TLR) (1) Topoisomerase (1) Tyrosinase (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0095

(S)-10-Hydroxycamptothecin 10-HCPT; 10-Hydroxycamptothecin	Topoisomerase Apoptosis	Cancer
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment .

HY-N3665

Cyclocommunol	Tyrosinase	Cancer
Cyclocommunol is a prenylflavonoid with antityrosinase and antiplatelet activitie, can be solated from breadfruit. Cyclocommunol exerts anti-tumor activity and inhibits the growth of human hepatoma and gastric cancer cells with IC₅₀ values between 16 and 80 µM. Cyclocommunol shows proapoptotic effect on oral squamous cell carcinoma (OSCC) .

HY-158058

WYJ-2	Toll-like Receptor (TLR) Pyroptosis	Inflammation/Immunology Cancer
WYJ-2 is a selective agonist for toll-like receptor 2/1 (TLR2/1) with EC₅₀ of 18.57 nM in human TLR2 and TLR1 transient-cotransfected HEK 293T cells. WYJ-2 induces pyroptosis and exhibits anticancer activity against non-small cell lung cancer (NSCLC) .

HY-N1183

Taiwanhomoflavone A	Others	Cancer
Taiwanhomoflavone A is a C-methylated biflavone, that can be isolated from the stem of Cephalotaxus wilsoniana. Taiwanhomoflavone-A shows anticancer activity .

Cat. No.	Product Name

HY-L101

Anti-Liver Cancer Compound Library	1,828 compounds
Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers. Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc. MCE offers a unique collection of 1,828 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Anti-Liver Cancer Compound Library

1,828 compounds

Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.

Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc.

MCE offers a unique collection of 1,828 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0095

(S)-10-Hydroxycamptothecin 10-HCPT; 10-Hydroxycamptothecin	Structural Classification Pyrrole Alkaloids Classification of Application Fields Source classification Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Alkaloids Monophenols Phenols Disease Research Fields Cancer	Topoisomerase Apoptosis
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment .

HY-N3665

Cyclocommunol	Flavonoids Source classification Distemonanthus benthamianus Baill. Plants Compositae Other Flavonoids	Tyrosinase
Cyclocommunol is a prenylflavonoid with antityrosinase and antiplatelet activitie, can be solated from breadfruit. Cyclocommunol exerts anti-tumor activity and inhibits the growth of human hepatoma and gastric cancer cells with IC₅₀ values between 16 and 80 µM. Cyclocommunol shows proapoptotic effect on oral squamous cell carcinoma (OSCC) .

HY-N1183

Taiwanhomoflavone A	Structural Classification Flavonoids Cephalotaxus sinensis var. wilsoniana (Hayata) L. K. Fu & Nan Li Taxaceae Source classification Plants Biflavones	Others
Taiwanhomoflavone A is a C-methylated biflavone, that can be isolated from the stem of Cephalotaxus wilsoniana. Taiwanhomoflavone-A shows anticancer activity .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Screening Libraries

Natural
Products

Name
Email *

	Sorry, but the email address you supplied was invalid.

hepatoma carcinoma

Inhibitors & Agonists

Screening Libraries

NaturalProducts

Natural
Products