Withaferin A

By Targets:	Apoptosis (3) Ferroptosis (1) NF-κB (2) PKA (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Inflammation/Immunology (3) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2065

Withaferin A 5 Publications Verification	NF-κB Ferroptosis	Inflammation/Immunology Cancer
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N10352

*4-epi-Withaferin* A**	Others	Cancer
4-epi-Withaferin A (compound 28) is the analogue of Withaferin A. 4-epi-Withaferin A enhances cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). 4-epi-Withaferin A has the potential for the research of protein aggregation-associated diseases by stimulating cellular defense mechanisms .

HY-138146

4-Dehydrowithaferin A 4-oxo Withaferin A	Others	Cancer
4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .

HY-N10357

3-Ethylthio withaferin A

Others Others

3-Ethylthio withaferin A is a derivative of Withaferin A. Withaferin A is a NF-kB inhibitor.
HY-N10353

4-Methyl withaferin A

Others Inflammation/Immunology Cancer

4-Methyl withaferin A is a withaferin A-analogue with anti-tumor activity .

*3-Ethylthio withaferin* A**	Others	Others
3-Ethylthio withaferin A is a derivative of Withaferin A. Withaferin A is a NF-kB inhibitor.

*4-Methyl withaferin* A**	Others	Inflammation/Immunology Cancer
4-Methyl withaferin A is a withaferin A-analogue with anti-tumor activity .

HY-N10358

*3-(2-Hydroxyethyl) thio withaferin* A**	NF-κB	Others
3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding .

HY-N10356

*4,27-Dimethyl withaferin* A**	Others	Neurological Disease
4,27-Dimethyl withaferin A is a synthetic analog of withanolide natural products. 4,27-Dimethyl withaferin A has the potential for the research of neurodegenerative diseases (extracted from patent WO2015077780A1) .

HY-N5046

27-O-Acetyl-withaferin A

Others Inflammation/Immunology

27-O-Acetyl-withaferin A is found in Withania aristata .

*27-O-Acetyl-withaferin* A**	Others	Inflammation/Immunology
27-O-Acetyl-withaferin A is found in Withania aristata .

HY-N10354

*27-Methyl withaferin* A**	Apoptosis	Cancer
27-Methyl withaferin A (comppund 26) is an apoptosis inducer with anticancer effects. 27-Methyl withaferin A shows antiproliferative effects against HeLa, A-549 and MCF-7 human tumor cell lines with IC₅₀ values of 3.2 μM, 4.2 μM and 1.4 μM, respectively .

HY-N10351

*27-O-(tert-Butyldimethylsilyl)withaferin* A**	Apoptosis	Cancer
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-N10355

27-TBDMS-4-Dehydrowithaferin A	Apoptosis	Cancer
27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent .

HY-P10319

RI-STAD-2	PKA	Cardiovascular Disease Cancer
RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer .

Cat. No.	Product Name	Target	Research Area

HY-P10319

RI-STAD-2	PKA	Cardiovascular Disease Cancer
RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2065

Withaferin A 5 Publications Verification	Structural Classification other families Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Inflammation/Immunology Disease Research Fields Steroids	NF-κB Ferroptosis
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N10352

*4-epi-Withaferin* A**	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Others
4-epi-Withaferin A (compound 28) is the analogue of Withaferin A. 4-epi-Withaferin A enhances cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). 4-epi-Withaferin A has the potential for the research of protein aggregation-associated diseases by stimulating cellular defense mechanisms .

HY-138146

4-Dehydrowithaferin A 4-oxo Withaferin A	Quinones Classification of Application Fields Source classification Benzene Quinones Withania somnifera Plants Solanaceae Disease Research Fields Cancer	Others
4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .

HY-N10357

*3-Ethylthio withaferin* A**	Classification of Application Fields Source classification Other Diseases Withania somnifera Plants Solanaceae Disease Research Fields Steroids	Others
3-Ethylthio withaferin A is a derivative of Withaferin A. Withaferin A is a NF-kB inhibitor.

HY-N10353

*4-Methyl withaferin* A**	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Inflammation/Immunology Steroids	Others
4-Methyl withaferin A is a withaferin A-analogue with anti-tumor activity .

HY-N10358

*3-(2-Hydroxyethyl) thio withaferin* A**	Classification of Application Fields Source classification Other Diseases Withania somnifera Plants Solanaceae Disease Research Fields Steroids	NF-κB
3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding .

HY-N10356

*4,27-Dimethyl withaferin* A**	Source classification Withania somnifera Plants Solanaceae Steroids	Others
4,27-Dimethyl withaferin A is a synthetic analog of withanolide natural products. 4,27-Dimethyl withaferin A has the potential for the research of neurodegenerative diseases (extracted from patent WO2015077780A1) .

HY-N5046

*27-O-Acetyl-withaferin* A**	other families Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology Steroids	Others
27-O-Acetyl-withaferin A is found in Withania aristata .

HY-N10351

*27-O-(tert-Butyldimethylsilyl)withaferin* A**	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-N10355

27-TBDMS-4-Dehydrowithaferin A	Quinones Classification of Application Fields Source classification Benzene Quinones Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent .

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Withaferin A

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