AKI

By Targets:	5-HT Receptor (2) Adrenergic Receptor (2) Apoptosis (6) Aurora Kinase (1) Autophagy (1) c-Met/HGFR (1) Calcium Channel (4) Caspase (4) DNA Stain (1) Dopamine Receptor (2) Endogenous Metabolite (1) Ferroptosis (3) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) MDM-2/p53 (2) Mitophagy (1) NF-κB (1) NO Synthase (1) Opioid Receptor (1) Parasite (1) PINK1/Parkin (1) Pyroptosis (2) Reactive Oxygen Species (4) Sigma Receptor (2) Sirtuin (2) Small Interfering RNA (siRNA) (1) Sodium Channel (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (9) Metabolic Disease (2) Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123159

AKI603	Aurora Kinase	Cancer
AKI603 is an inhibitor of Aurora kinase A (AurA), with an IC₅₀ of 12.3 nM. AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells .

HY-B1391

D-Panthenol Dexpanthenol	Endogenous Metabolite	Inflammation/Immunology Cancer
D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration.

HY-B0347

Lacidipine 1 Publications Verification	Calcium Channel Reactive Oxygen Species Caspase Apoptosis	Cardiovascular Disease
Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-149425

SIRT5 inhibitor 6	Sirtuin	Inflammation/Immunology Cancer
SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC₅₀ of 3.0 μM. SIRT5 Inhibitor6 has a therapeutic potential against septic AKI in vivo .

HY-B0347S3

Lacidipine-13C4	Calcium Channel Caspase Reactive Oxygen Species Apoptosis Isotope-Labeled Compounds	Cardiovascular Disease
Lacidipine- ¹³C₄ is ¹³C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-B0347R

Lacidipine (Standard)	Calcium Channel Reactive Oxygen Species Caspase Apoptosis	Cardiovascular Disease
Lacidipine (Standard) is the analytical standard of Lacidipine. This product is intended for research and analytical applications. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-P3434

Ac-FEID-CMK	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-P3434A

Ac-FEID-CMK TFA	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-151342

Ser@TPP@CUR	Others	Others
Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .

HY-132595A

Teprasiran sodium QPI-1002 sodium	MDM-2/p53	Cancer
Teprasiran sodium is a small interfering RNA that temporarily inhibits p53-mediated cell death that underlies acute kidney injury (AKI) .

HY-132595

Teprasiran QPI-1002	Small Interfering RNA (siRNA) MDM-2/p53	Cancer
Teprasiran (QPI-1002) is a small interfering RNA that temporarily inhibits p53-mediated cell death that underlies acute kidney injury (AKI) .

HY-149594

CL-Pa	Others	Metabolic Disease
CL-Pa is a chemiluminescent probe suitable for detection of urinary Vanin-1. CL-Pa can be used to detect drug-induced acute kidney injury (AKI) through urinalysis .

HY-B0347S1

Lacidipine-13C8	Apoptosis Caspase Calcium Channel Reactive Oxygen Species	Cardiovascular Disease
Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

HY-N2995

Poricoic acid A Poricoic acid A(F)	NF-κB Keap1-Nrf2	Cancer
Poricoic acid A, isolated from Poria cocos, possesses anti-tumor activity . Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis .

HY-149719

Ferroptosis-IN-4	Ferroptosis	Metabolic Disease
Ferroptosis-IN-4 (compound 6k) is a ferroptosis inhibitor with EC₅₀ value of 20 μM. Ferroptosis-IN-4 has no obvious cytotoxicity. Ferroptosis-IN-4 has a protective effect in glycerol-induced RM-AKI mice with alleviating kidney dysfunction .

HY-13575

Blonanserin AD-5423	5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Neurological Disease
Blonanserin (AD-5423) is a potent and orally active *5-HT_2A* (K_i=0.812 nM) and dopamine D2 receptor (K_i=0.142 nM) antagonist. Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension .

HY-44307

84-B10	Ferroptosis	Cancer
84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI) .

HY-137455

Terevalefim

ANG-3777
c-Met/HGFR Inflammation/Immunology

Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor .

Terevalefim ANG-3777	c-Met/HGFR	Inflammation/Immunology
Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor .

HY-13575R

Blonanserin (Standard)	5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Neurological Disease
Blonanserin (Standard) is the analytical standard of Blonanserin. This product is intended for research and analytical applications. Blonanserin (AD-5423) is a potent and orally active *5-HT_2A* (K_i=0.812 nM) and dopamine D2 receptor (K_i=0.142 nM) antagonist. Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension .

HY-149426

SIRT5 inhibitor 7	Sirtuin	Inflammation/Immunology
SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury .

HY-13735

Quinacrine Acriquine	Parasite Sodium Channel DNA Stain Apoptosis	Infection Neurological Disease Cancer
Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC₅₀: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm) .

HY-144332

PHD2/HDACs-IN-1	HDAC HIF/HIF Prolyl-Hydroxylase	Cancer
PHD2/HDACs-IN-1 is a potent PHD2/HDACs hybrid inhibitor (IC₅₀s of 1.15 μM, 19.75 μM, 26.60 μM and 15.98 μM for PHD2, HDAC1, HDAC2 and HDAC6, respectively). PHD2/HDACs-IN-1 is a low-toxicity renoprotective agent for research of cisplatin-induced acute kidney injury (AKI) .

HY-N0164

Matrine Maximum Cited Publications 12 Publications Verification Matridin-15-one; Vegard; α-Matrine	PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis	Inflammation/Immunology Cancer
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

HY-12118

L-NIL dihydrochloride

NO Synthase Inflammation/Immunology

L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC₅₀ of 3.3 μM for miNOS .

L-NIL dihydrochloride	NO Synthase	Inflammation/Immunology
L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC₅₀ of 3.3 μM for miNOS .

HY-P99198

Fletikumab NNC 0109-0012	Interleukin Related	Inflammation/Immunology
Fletikumab (NNC0109-0012) is a monoclonal antibody targeting to IL-20. Fletikumab can be used for inflammation research, such as rheumatoid arthritis .

Cat. No.	Product Name	Type

HY-E70022

D-Mannose isomerase (PsMaSeAF)	Biochemical Assay Reagents
D-Mannose isomerase (PsMaSeAF) is a carbohydrate isomerase catalyzing the reversible isomerization of d-mannose to d-fructose. D-Mannose isomerase (PsMaSeAF) belongs to the N-acylglucosamine 2-epimerase (AGE) superfamily along with AGE, cellobiose 2-epimerase (CE), and aldose-ketose isomerase (AKI) .

Cat. No.	Product Name	Target	Research Area

HY-P3434A

Ac-FEID-CMK TFA	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK TFA is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK TFA can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK TFA inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK TFA can suppress the caspy2-mediated noncanonical inflammasome pathway .

HY-P3434

Ac-FEID-CMK	Pyroptosis	Inflammation/Immunology
Ac-FEID-CMK is a potent zebrafish-specific GSDMEb-derived peptide inhibitor. Ac-FEID-CMK can attenuate the mortality and kidney injury during septic shock. Ac-FEID-CMK inhibits pyroptosis and attenuates septic AKI (acute kidney injury) in vivo. Ac-FEID-CMK can suppress the caspy2-mediated noncanonical inflammasome pathway .

Cat. No.	Product Name	Target	Research Area

HY-P99198

Fletikumab NNC 0109-0012	Interleukin Related	Inflammation/Immunology
Fletikumab (NNC0109-0012) is a monoclonal antibody targeting to IL-20. Fletikumab can be used for inflammation research, such as rheumatoid arthritis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1391

D-Panthenol Dexpanthenol	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration.

HY-N2995

Poricoic acid A Poricoic acid A(F)	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Polyporaceae Poria cocos Plants Disease Research Fields Cancer	NF-κB Keap1-Nrf2
Poricoic acid A, isolated from Poria cocos, possesses anti-tumor activity . Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis .

HY-N0164

Matrine 10+ Cited Publications Matridin-15-one; Vegard; α-Matrine	Structural Classification Classification of Application Fields Source classification Sophora flavescens Aiton Plants Biological Pesticide Research Agricultural Research Alkaloids Piperidine Alkaloids Leguminosae Inflammation/Immunology Disease Research Fields Cancer	PINK1/Parkin Opioid Receptor Autophagy Mitophagy Ferroptosis Apoptosis
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI) .

Cat. No.	Product Name	Chemical Structure

HY-B0347S3

Lacidipine-13C4
Lacidipine- ¹³C₄ is ¹³C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

Lacidipine-13C4

Lacidipine- ¹³C₄ is ¹³C labeled Lacidipine (HY-B0347). Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI) .

HY-B0347S1

Lacidipine-13C8
Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

Lacidipine-13C8

Lacidipine- ¹³C₈ is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83257

CC2D1A Antibody (YA3002)

Coiled coil and C2 domain containing 1A; FREUD 1; Freud 1/AKI1; MRT3
WB, ICC/IF, FC Human, Mouse, Rat


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