2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. SAH-d4

SAH-d4  (Synonyms: SAH (S-Adenosylhomocysteine)-d4)

Cat. No.: HY-19528S Purity: ≥98.0%
COA Handling Instructions

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SAH-d4 is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

For research use only. We do not sell to patients.

SAH-d<sub>4</sub> Chemical Structure

SAH-d4 Chemical Structure

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1 mg USD 620 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of SAH-d4:

SAH-d4 Related Antibodies

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Description

SAH-d4 is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SAH-d4 Related Antibodies
Molecular Weight

388.44

Formula

C14H16D4N6O5S
Unlabeled Cas

979-92-0
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CSC([2H])([2H])C([2H])([2H])[C@H](N)C(O)=O)[C@@H](O)[C@H]3O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (160.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5744 mL 12.8720 mL 25.7440 mL
5 mM 0.5149 mL 2.5744 mL 5.1488 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5744 mL 12.8720 mL 25.7440 mL 64.3600 mL
5 mM 0.5149 mL 2.5744 mL 5.1488 mL 12.8720 mL
10 mM 0.2574 mL 1.2872 mL 2.5744 mL 6.4360 mL
15 mM 0.1716 mL 0.8581 mL 1.7163 mL 4.2907 mL
20 mM 0.1287 mL 0.6436 mL 1.2872 mL 3.2180 mL
25 mM 0.1030 mL 0.5149 mL 1.0298 mL 2.5744 mL
30 mM 0.0858 mL 0.4291 mL 0.8581 mL 2.1453 mL
40 mM 0.0644 mL 0.3218 mL 0.6436 mL 1.6090 mL
50 mM 0.0515 mL 0.2574 mL 0.5149 mL 1.2872 mL
60 mM 0.0429 mL 0.2145 mL 0.4291 mL 1.0727 mL
80 mM 0.0322 mL 0.1609 mL 0.3218 mL 0.8045 mL
100 mM 0.0257 mL 0.1287 mL 0.2574 mL 0.6436 mL
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SAH-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAH-d4SAH (S-Adenosylhomocysteine)-d4Endogenous MetaboliteInhibitorinhibitorinhibit

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