Prucalopride-¹³C,d₃

Name: Prucalopride- 13 C,d 3
Brand: MedChemExpress
SKU: HY-14151S
Rating: 4.5 (1 reviews)

Cat. No.: HY-14151S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Prucalopride-¹³C,d₃ is the ¹³C- and deuterium labeled Prucalopride[1].

For research use only. We do not sell to patients.

Prucalopride-<sup>13</sup>C,d<sub>3</sub> Chemical Structure

Prucalopride-¹³C,d₃ Chemical Structure

CAS No. : 2140306-00-7

Size	Price	Stock	Quantity
1 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 2380	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 3600	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Prucalopride-¹³C,d₃:

Prucalopride In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

Biological Activity
Purity & Documentation
References
Customer Review

Description

Prucalopride-¹³C,d₃ is the ¹³C- and deuterium labeled Prucalopride[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[24].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

371.88

Formula

C₁₇¹³CH₂₃D₃ClN₃O₃

CAS No.

2140306-00-7

Unlabeled Cas

179474-81-8

Appearance

Solid

Color

White to off-white

SMILES

[2H][13C]([2H])([2H])OCCCN(CC1)CCC1NC(C2=C3C(CCO3)=C(C(Cl)=C2)N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H2O : 50 mg/mL (134.45 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6890 mL	13.4452 mL	26.8904 mL
5 mM	0.5378 mL	2.6890 mL	5.3781 mL
10 mM	0.2689 mL	1.3445 mL	2.6890 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (246 KB) HNMR (118 KB) LCMS (135 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]

[2]. Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83. [Content Brief]

[3]. Emmanuel AV, et al. Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction--a double-blind, placebo-controlled, cross-over, multiple n = 1 study. Aliment Pharmacol Ther. 2012 Jan;35(1):48-55. [Content Brief]

[4]. Bouras EP, et al. Selective stimulation of colonic transit by the benzofuran 5HT4 agonist, prucalopride, in healthy humans. Gut. 1999 May;44(5):682-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H2O	1 mM	2.6890 mL	13.4452 mL	26.8904 mL	67.2260 mL
	5 mM	0.5378 mL	2.6890 mL	5.3781 mL	13.4452 mL
	10 mM	0.2689 mL	1.3445 mL	2.6890 mL	6.7226 mL
	15 mM	0.1793 mL	0.8963 mL	1.7927 mL	4.4817 mL
	20 mM	0.1345 mL	0.6723 mL	1.3445 mL	3.3613 mL
	25 mM	0.1076 mL	0.5378 mL	1.0756 mL	2.6890 mL
	30 mM	0.0896 mL	0.4482 mL	0.8963 mL	2.2409 mL
	40 mM	0.0672 mL	0.3361 mL	0.6723 mL	1.6806 mL
	50 mM	0.0538 mL	0.2689 mL	0.5378 mL	1.3445 mL
	60 mM	0.0448 mL	0.2241 mL	0.4482 mL	1.1204 mL
	80 mM	0.0336 mL	0.1681 mL	0.3361 mL	0.8403 mL
	100 mM	0.0269 mL	0.1345 mL	0.2689 mL	0.6723 mL