2. PROTAC Epigenetics Cell Cycle/DNA Damage
  3. PROTACs PARP
  4. PROTAC PARP1 degrader

PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.

For research use only. We do not sell to patients.

PROTAC PARP1 degrader Chemical Structure

PROTAC PARP1 degrader Chemical Structure

CAS No. : 2369022-68-2

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1 mg USD 1130 In-stock
5 mg USD 2260 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of PROTAC PARP1 degrader:

PROTAC PARP1 degrader Related Antibodies

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Description

PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.

IC50 & Target[1]

PARP1

 

MDM2

 

Molecular Weight

1145.09

Formula

C58H63Cl2N11O10
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C(CN(C(N1C(C2=CC=C(OC)C=C2OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]1C4=CC=C(Cl)C=C4)=O)CC5)N5CC(NCCOCCOCCOCCOCCN6N=NC(C7=CC=C(N8N=C(C(C(N)=O)=CC=C9)C9=C8)C=C7)=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (87.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8733 mL 4.3665 mL 8.7329 mL
5 mM 0.1747 mL 0.8733 mL 1.7466 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8733 mL 4.3665 mL 8.7329 mL 21.8323 mL
5 mM 0.1747 mL 0.8733 mL 1.7466 mL 4.3665 mL
10 mM 0.0873 mL 0.4366 mL 0.8733 mL 2.1832 mL
15 mM 0.0582 mL 0.2911 mL 0.5822 mL 1.4555 mL
20 mM 0.0437 mL 0.2183 mL 0.4366 mL 1.0916 mL
25 mM 0.0349 mL 0.1747 mL 0.3493 mL 0.8733 mL
30 mM 0.0291 mL 0.1455 mL 0.2911 mL 0.7277 mL
40 mM 0.0218 mL 0.1092 mL 0.2183 mL 0.5458 mL
50 mM 0.0175 mL 0.0873 mL 0.1747 mL 0.4366 mL
60 mM 0.0146 mL 0.0728 mL 0.1455 mL 0.3639 mL
80 mM 0.0109 mL 0.0546 mL 0.1092 mL 0.2729 mL
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PROTAC PARP1 degrader Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC PARP1 degrader2369022-68-2PROTACsPARPpoly ADP ribose polymeraseInhibitorinhibitorinhibit

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