2. Protein Tyrosine Kinase/RTK Autophagy
  3. Bcr-Abl PDGFR VEGFR FGFR Src Autophagy
  4. Ponatinib-d8

Ponatinib-d8  (Synonyms: AP24534-d8)

Cat. No.: HY-12047S Purity: 99.91%
COA Handling Instructions

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Ponatinib-d8 is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

For research use only. We do not sell to patients.

Ponatinib-d<sub>8</sub> Chemical Structure

Ponatinib-d8 Chemical Structure

CAS No. : 1562993-37-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Ponatinib-d8:

Ponatinib-d8 Related Antibodies

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  • Biological Activity

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Description

Ponatinib-d8 is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

IC50 & Target[1]

c-Kit

12.5 nM (IC50)

VEGFR2

1.5 nM (IC50)

FGFR1

2.2 nM (IC50)

PDGFRα

1.1 nM (IC50)

Molecular Weight

540.61

Formula

C29H19D8F3N6O
CAS No.
Unlabeled CAS

943319-70-8
Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC1=CC=C(CN2C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C2([2H])[2H])C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M HCl : 50 mg/mL (92.49 mM; ultrasonic and adjust pH to 1 with HCl)

DMSO : 25 mg/mL (46.24 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8498 mL 9.2488 mL 18.4976 mL
5 mM 0.3700 mL 1.8498 mL 3.6995 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 1M HCl 1 mM 1.8498 mL 9.2488 mL 18.4976 mL 46.2441 mL
5 mM 0.3700 mL 1.8498 mL 3.6995 mL 9.2488 mL
10 mM 0.1850 mL 0.9249 mL 1.8498 mL 4.6244 mL
15 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0829 mL
20 mM 0.0925 mL 0.4624 mL 0.9249 mL 2.3122 mL
25 mM 0.0740 mL 0.3700 mL 0.7399 mL 1.8498 mL
30 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5415 mL
40 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1561 mL
1M HCl 50 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9249 mL
60 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.7707 mL
80 mM 0.0231 mL 0.1156 mL 0.2312 mL 0.5781 mL
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Ponatinib-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ponatinib-d81562993-37-6AP24534-d8Bcr-AblPDGFRVEGFRFGFRSrcAutophagyPlatelet-derived growth factor receptorVascular endothelial growth factor receptorFibroblast growth factor receptororallyactivemulti-targetedkinaseAblPDGFRαVEGFR2FGFR1Inhibitorinhibitorinhibit

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