2. MAPK/ERK Pathway
  3. MEK
  4. PD 198306

PD 198306 is a selective MAPK/ERK-kinase (MEK) inhibitor. PD 198306 results in an observable reduction in the Streptozocin induced increase in the level of active ERK1 and 2. Antihyperalgesic effects.

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PD 198306 Chemical Structure

PD 198306 Chemical Structure

CAS No. : 212631-61-3

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Based on 1 publication(s) in Google Scholar

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Description

PD 198306 is a selective MAPK/ERK-kinase (MEK) inhibitor. PD 198306 results in an observable reduction in the Streptozocin induced increase in the level of active ERK1 and 2. Antihyperalgesic effects[1].

IC50 & Target[1]

MEK

 

In Vitro

PD198306 significantly inhibits Tha-GFP replication by 25% at 10 μM, after 36 h[2].
PD198306 (5 μM) reduces Tha-Crimson replication significantly by 20% at 18 h but such a result could not be confirmed at 36 h[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PD 198306 Related Antibodies

Cell Cycle Analysis[2]

Cell Line: Human induced pluripotent stem cells (iPSC)
Concentration: 10  μM
Incubation Time: 6  hours
Result: Inhibited Tha-Crimson replication at 10 μM, reducing it by 30% at 18 h and 50% at 36 h.
In Vivo

Intrathecal administration of PD 198306 (1-30 μg per 10 μL) dose-dependently (1-30 μg) blocks static allodynia in both the streptozocin and the chronic constriction injury (CCI) models of neuropathic pain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (250-300 g) bearing neuropathic pain[1]
Dosage: 1-30 μg per 10 μL and 3 mg per 100 μL (PD 198306 is suspended in cremophor:ethanol:water, 1 : 1 : 8.)
Administration: Single doses of intrathecal (i.t.) or intraplantar (ipl) of PD 198306 (1-30 μg per 10 μL and 3 mg per 100 μL respectively
Result: Intrathecal administration dose-dependently (1-30 μg) blocked static allodynia the streptozocin model of neuropathic pain.
The minimum effective doses (MED) of 3 μg significantly blocked static allodynia 30 min after treatment.
Both 10 μg and the highest dose used (30 μg) totally blocked the maintenance of static allodynia, for up to 1 h.
Molecular Weight

476.23

Formula

C18H16F3IN2O2
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C(NOCC1CC1)C(C=C(F)C(F)=C2F)=C2NC3=C(C=C(I)C=C3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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PD 198306 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD 198306212631-61-3PD198306PD-198306MEKMitogen-activated protein kinase kinaseMAPKKMAP2KRNAinterferencedrugscreeninginositolphosphatephosphatasesmitogen-activated proteinkinasesrabiesMAPKERKantihyperalgesicneuropathicpainInhibitorinhibitorinhibit

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