Ondansetron-d₃ hydrochloride

Cat. No.: HY-B0002S Purity: 98.78%: FAQs
Data Sheet SDS COA Handling Instructions

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Ondansetron-d₃ (hydrochloride) is the deuterium labeled Ondansetron hydrochloride. Ondansetron hydrochloride (GR 38032 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[1][2].

For research use only. We do not sell to patients.

Ondansetron-d<sub>3</sub> hydrochloride Chemical Structure

Ondansetron-d₃ hydrochloride Chemical Structure

CAS No. : 1346605-02-4

Size	Price	Stock	Quantity
1 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Other Forms of Ondansetron-d₃ hydrochloride:

Ondansetron hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

296.39

Formula

C₁₈H₁₇D₃ClN₃O

CAS No.

1346605-02-4

Unlabeled CAS

99614-02-5

Appearance

Solid

Color

Off-white to light brown

SMILES

O=C1C=2C=3C(N(C([2H])([2H])[2H])C2CCC1CN4C(C)=NC=C4)=CC=CC3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 33 mg/mL (111.34 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3739 mL	16.8697 mL	33.7393 mL
5 mM	0.6748 mL	3.3739 mL	6.7479 mL
10 mM	0.3374 mL	1.6870 mL	3.3739 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.78%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (252 KB) Elemental Analysis Report (111 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A). J Physiol. 1998 Mar 15;507 ( Pt 3):653-65. [Content Brief]

[3]. Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362(3):255-65. [Content Brief]

[4]. Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50. [Content Brief]

[5]. Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20(6):1103-16. [Content Brief]

[6]. Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20(1):78-83. [Content Brief]

[7]. Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12(3):421-31. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3739 mL	16.8697 mL	33.7393 mL	84.3483 mL
	5 mM	0.6748 mL	3.3739 mL	6.7479 mL	16.8697 mL
	10 mM	0.3374 mL	1.6870 mL	3.3739 mL	8.4348 mL
	15 mM	0.2249 mL	1.1246 mL	2.2493 mL	5.6232 mL
	20 mM	0.1687 mL	0.8435 mL	1.6870 mL	4.2174 mL
	25 mM	0.1350 mL	0.6748 mL	1.3496 mL	3.3739 mL
	30 mM	0.1125 mL	0.5623 mL	1.1246 mL	2.8116 mL
	40 mM	0.0843 mL	0.4217 mL	0.8435 mL	2.1087 mL
	50 mM	0.0675 mL	0.3374 mL	0.6748 mL	1.6870 mL
	60 mM	0.0562 mL	0.2812 mL	0.5623 mL	1.4058 mL
	80 mM	0.0422 mL	0.2109 mL	0.4217 mL	1.0544 mL
	100 mM	0.0337 mL	0.1687 mL	0.3374 mL	0.8435 mL