Octyl glucose neopentyl glycol (Synonyms: OGNG)

Name: Octyl glucose neopentyl glycol
Brand: MedChemExpress
SKU: HY-138192
Rating: 4.5 (1 reviews)

Cat. No.: HY-138192 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Octyl glucose neopentyl glycol (OGNG) is a neopentyl glycol detergent that can be used to maintain the stability of membrane proteins.

For research use only. We do not sell to patients.

Octyl glucose neopentyl glycol Chemical Structure

CAS No. : 1257853-32-9

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100 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Octyl glucose neopentyl glycol (OGNG) is a neopentyl glycol detergent that can be used to maintain the stability of membrane proteins^[1].

In Vitro

The decisive step, in the improvement of Thermotoga maritima (TmPPase) crystal quality came through detergent exchange in to Octyl glucose neopentyl glycol, a neopentyl glycol detergent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

568.69

Formula

C₂₇H₅₂O₁₂

CAS No.

1257853-32-9

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCC(CO[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)(CCCCCC)CO[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (439.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (175.84 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7584 mL	8.7921 mL	17.5843 mL
5 mM	0.3517 mL	1.7584 mL	3.5169 mL
10 mM	0.1758 mL	0.8792 mL	1.7584 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 6.25 mg/mL (10.99 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 6.25 mg/mL (10.99 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 6.25 mg/mL (10.99 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (175.84 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (249 KB) HNMR (270 KB)

Handling Instructions (2659 KB)

References

[1]. Juho Kellosalo, et al. Crystallization and preliminary X-ray analysis of membrane-bound pyrophosphatases. Mol Membr Biol. 2013 Feb;30(1):64-74. [Content Brief]

[2]. Muhammad Ehsan, et al. New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability. ACS Chem Biol. 2020 Jun 19;15(6):1697-1707. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.7584 mL	8.7921 mL	17.5843 mL	43.9607 mL
	5 mM	0.3517 mL	1.7584 mL	3.5169 mL	8.7921 mL
	10 mM	0.1758 mL	0.8792 mL	1.7584 mL	4.3961 mL
	15 mM	0.1172 mL	0.5861 mL	1.1723 mL	2.9307 mL
	20 mM	0.0879 mL	0.4396 mL	0.8792 mL	2.1980 mL
	25 mM	0.0703 mL	0.3517 mL	0.7034 mL	1.7584 mL
	30 mM	0.0586 mL	0.2931 mL	0.5861 mL	1.4654 mL
	40 mM	0.0440 mL	0.2198 mL	0.4396 mL	1.0990 mL
	50 mM	0.0352 mL	0.1758 mL	0.3517 mL	0.8792 mL
	60 mM	0.0293 mL	0.1465 mL	0.2931 mL	0.7327 mL
	80 mM	0.0220 mL	0.1099 mL	0.2198 mL	0.5495 mL
	100 mM	0.0176 mL	0.0879 mL	0.1758 mL	0.4396 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Octyl glucose neopentyl glycol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Octyl glucose neopentyl glycol1257853-32-9OGNGOthersneopentylglycoldetergentmembraneproteinsInhibitorinhibitorinhibit

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Octyl glucose neopentyl glycol (Synonyms: OGNG)

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Octyl glucose neopentyl glycol Related Antibodies

Featured Recommendations

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Biological Activity

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References

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Octyl glucose neopentyl glycol Related Antibodies

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Complete Stock Solution Preparation Table

Octyl glucose neopentyl glycol Related Classifications

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