Oclacitinib-¹³C-d₃

Name: Oclacitinib- 13 C-d 3
Brand: MedChemExpress
SKU: HY-13577S
Rating: 4.5 (1 reviews)

Cat. No.: HY-13577S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Oclacitinib-¹³C-d₃ is the deuterium and ¹³C labeled Oclacitinib[1].

For research use only. We do not sell to patients.

Oclacitinib-<sup>13</sup>C-d<sub>3</sub> Chemical Structure

Oclacitinib-¹³C-d₃ Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Oclacitinib-¹³C-d₃:

Oclacitinib In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Oclacitinib-¹³C-d₃ is the deuterium and ¹³C labeled Oclacitinib[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

341.45

Formula

C₁₄¹³CH₂₀D₃N₅O₂S

Unlabeled CAS

1208319-26-9

Appearance

Solid

Color

White to off-white

SMILES

CNS(C[C@@H]1CC[C@H](CC1)N([13C]([2H])([2H])[2H])C2=NC=NC3=C2C=CN3)(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : ≥ 14 mg/mL (41.00 mM)

DMSO : ≥ 12 mg/mL (35.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF:PBS (pH 7.2) (1:1) : ≥ 0.5 mg/mL (1.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9287 mL	14.6434 mL	29.2869 mL
5 mM	0.5857 mL	2.9287 mL	5.8574 mL
10 mM	0.2929 mL	1.4643 mL	2.9287 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (253 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF:PBS (pH 7.2) (1:1) / DMSO / DMF	1 mM	2.9287 mL	14.6434 mL	29.2869 mL	73.2172 mL
DMSO / DMF	5 mM	0.5857 mL	2.9287 mL	5.8574 mL	14.6434 mL
	10 mM	0.2929 mL	1.4643 mL	2.9287 mL	7.3217 mL
	15 mM	0.1952 mL	0.9762 mL	1.9525 mL	4.8811 mL
	20 mM	0.1464 mL	0.7322 mL	1.4643 mL	3.6609 mL
	25 mM	0.1171 mL	0.5857 mL	1.1715 mL	2.9287 mL
	30 mM	0.0976 mL	0.4881 mL	0.9762 mL	2.4406 mL
DMF	40 mM	0.0732 mL	0.3661 mL	0.7322 mL	1.8304 mL