2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Potassium Channel Dipeptidyl Peptidase
  4. Nateglinide-d5

Nateglinide-d5  (Synonyms: A4166 d5; Senaglinide d5)

Cat. No.: HY-B0422S Purity: ≥98.0%
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Nateglinide-d5 is a deuterium labeled Nateglinide. Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K+ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus[1][2].

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Nateglinide-d<sub>5</sub> Chemical Structure

Nateglinide-d5 Chemical Structure

CAS No. : 1227666-13-8

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Based on 1 publication(s) in Google Scholar

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Nateglinide-d5 Related Antibodies

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Description

Nateglinide-d5 is a deuterium labeled Nateglinide. Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K+ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus[1][2].

IC50 & Target

DPP-4

 

Molecular Weight

322.45

Formula

C19H22D5NO3
CAS No.
Unlabeled CAS

105816-04-4
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](CC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])NC([C@H]2CC[C@H](C(C)C)CC2)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (310.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1013 mL 15.5063 mL 31.0126 mL
5 mM 0.6203 mL 3.1013 mL 6.2025 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1013 mL 15.5063 mL 31.0126 mL 77.5314 mL
5 mM 0.6203 mL 3.1013 mL 6.2025 mL 15.5063 mL
10 mM 0.3101 mL 1.5506 mL 3.1013 mL 7.7531 mL
15 mM 0.2068 mL 1.0338 mL 2.0675 mL 5.1688 mL
20 mM 0.1551 mL 0.7753 mL 1.5506 mL 3.8766 mL
25 mM 0.1241 mL 0.6203 mL 1.2405 mL 3.1013 mL
30 mM 0.1034 mL 0.5169 mL 1.0338 mL 2.5844 mL
40 mM 0.0775 mL 0.3877 mL 0.7753 mL 1.9383 mL
50 mM 0.0620 mL 0.3101 mL 0.6203 mL 1.5506 mL
60 mM 0.0517 mL 0.2584 mL 0.5169 mL 1.2922 mL
80 mM 0.0388 mL 0.1938 mL 0.3877 mL 0.9691 mL
100 mM 0.0310 mL 0.1551 mL 0.3101 mL 0.7753 mL
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Nateglinide-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nateglinide-d51227666-13-8A4166 d5Senaglinide d5Potassium ChannelDipeptidyl PeptidaseKcsADPPglucoseinsulindiabetesshort-actingβ-cellInhibitorinhibitorinhibit

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