N,N'-Dimethylhydrazine dihydrochloride (Synonyms: 1,2-Dimethylhydrazine dihydrochloride)

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N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride is a tumor inducer that induces colon tumors in rodents.

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N,N'-Dimethylhydrazine dihydrochloride Chemical Structure

CAS No. : 306-37-6

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Description

N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride is a tumor inducer that induces colon tumors in rodents^[1]^[2].

In Vivo

N,N'-Dimethylhydrazine (DMH) (20 mg/kg; sc; once weekly, 24 wk) can induce colon cancer in ICR mice^[1].
N,N'-Dimethylhydrazine (20 mg/kg ; sc; 20 wk) induces intraperitoneal intestinal tumors in rats, an effect that is potently inhibited by Lactobacillus acidophilus. Mice that consumed a beef diet that mimicked a "Western" diet had a higher incidence of colon cancer than grain-fed mice (83% vs. 31%, respectively)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ICR mouse^[1]
Dosage:	20 mg/kg
Administration:	sc; once weekly for 24 weeks; sacrificed mouse after between 23 and 33 weeks.
Result:	Induced colon cancer in ICR mice.

Animal Model:	Male inbred F344 rats^[1]
Dosage:	20 mg, 4 mg/mL dissolved in normal saline containing 1.5% EDTA (pH 6.4 and filter sterilized)
Administration:	sc; weekly for 20 or 35 weeks
Result:	Produced a higher incidence of adenocarcinomas in the small and large intestines of animals that were consuming the meat diet.

Molecular Weight

133.02

Formula

C₂H₁₀Cl₂N₂

CAS No.

306-37-6

Unlabeled CAS

Appearance

Solid

SMILES

CNNC.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nakamura S, et al. Morphogenesis of colonic adenomas in mice treated with N,N'-dimethylhydrazine dihydrochloride. Acta Pathol Jpn. 1982 May;32(3):473-81. [Content Brief]

[2]. Goldin BR, et al. Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. J Natl Cancer Inst. 1980 Feb;64(2):263-5. [Content Brief]

N,N'-Dimethylhydrazine dihydrochloride Related Classifications

Biochemical Assay Reagents

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N,N'-Dimethylhydrazine306-37-61,2-DimethylhydrazineBiochemical Assay Reagentstumor inducerInhibitorinhibitorinhibit

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