ML353 

ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an K_i value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a agent blocker^[1]. ML353 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

ML353 is a fully soluble compound with a solubility of 16.9 µM or 6.0 µg/mL in PBS (PH=7.4)^[1].
ML353 has excellent stability in PBS buffer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

306.33

C₁₉H₁₅FN₂O

2990506-75-5

Solid

White to off-white

O=C(C1=NC=C(C#CC2=CC(F)=CC=C2)C=C1)N(C3)CC4C3C4

Room temperature in continental US; may vary elsewhere.

• [1]. Gregory KJ, et al. Identification of a high affinity MPEP-site silent allosteric modulator (SAM) for the metabotropic glutamate subtype 5 receptor (mGlu5). 2013 Apr 15 [updated 2015 Feb 11]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.  [Content Brief]