Minoxidil-d₁₀

Name: Minoxidil-d 10
Brand: MedChemExpress
SKU: HY-23196S
Rating: 5.0 (1 reviews)

Cat. No.: HY-23196S Purity: 99.70%: FAQs
Data Sheet SDS COA Handling Instructions

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Minoxidil-d₁₀ (U10858-d10) is the deuterium labeled Minoxidil. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

For research use only. We do not sell to patients.

Minoxidil-d<sub>10</sub> Chemical Structure

Minoxidil-d₁₀ Chemical Structure

CAS No. : 1020718-66-4

Size	Price	Stock	Quantity
1 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Minoxidil-d₁₀:

Minoxidil In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

219.31

Formula

C₉H₅D₁₀N₅O

CAS No.

1020718-66-4

Unlabeled CAS

38304-91-5

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(N2C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C2([2H])[2H])=CC(N)=[N+]1[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : ≥ 5 mg/mL (22.80 mM)

DMF : ≥ 2 mg/mL (9.12 mM)

DMSO : ≥ 2 mg/mL (9.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

PBS (pH 7.2) : ≥ 2 mg/mL (9.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5598 mL	22.7988 mL	45.5976 mL
5 mM	0.9120 mL	4.5598 mL	9.1195 mL
10 mM	0.4560 mL	2.2799 mL	4.5598 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.70%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (256 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Cox L, et al. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database Syst Rev. 2015;2015(11):CD009420. Published 2015 Nov 2. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / DMSO / PBS (pH 7.2) / Ethanol	1 mM	4.5598 mL	22.7988 mL	45.5976 mL	113.9939 mL
DMF / DMSO / PBS (pH 7.2) / Ethanol	5 mM	0.9120 mL	4.5598 mL	9.1195 mL	22.7988 mL
Ethanol	10 mM	0.4560 mL	2.2799 mL	4.5598 mL	11.3994 mL
	15 mM	0.3040 mL	1.5199 mL	3.0398 mL	7.5996 mL
	20 mM	0.2280 mL	1.1399 mL	2.2799 mL	5.6997 mL