2. Neuronal Signaling GPCR/G Protein Protein Tyrosine Kinase/RTK
  3. mGluR Src
  4. mG2N001

mG2N001 is a negative allosteric modulator (NAM) (IC50: 93 nM) of the metabotropic glutamate receptor mGluR2 and binds to mGluR2 as an antagonist (Ki: 63 nM). mG2N001 is microparticle- and plasma-stable, and its radioisotope [11C]mG2N001 can be used in PET imaging. [11C]mG2N001 has good brain heterogeneity and brain penetration, and can selectively accumulate in mGluR2-rich regions, producing high-contrast brain images.

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mG2N001 Chemical Structure

mG2N001 Chemical Structure

CAS No. : 2760515-88-4

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mG2N001 Related Antibodies

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Description

mG2N001 is a negative allosteric modulator (NAM) (IC50: 93 nM) of the metabotropic glutamate receptor mGluR2 and binds to mGluR2 as an antagonist (Ki: 63 nM). mG2N001 is microparticle- and plasma-stable, and its radioisotope [11C]mG2N001 can be used in PET imaging. [11C]mG2N001 has good brain heterogeneity and brain penetration, and can selectively accumulate in mGluR2-rich regions, producing high-contrast brain images[1].

In Vivo

mG2N001 (63.0-87.3 MBq [11C]mG2N001, iv.) can perform PET imaging experiments in rats and cynomolgus monkeys, showing the specific binding activity of mGluR2, clearly showing the binding activity of mGluR2 in the animal brain Biological distribution map[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

330.35

Formula

C18H19FN2O3
CAS No.
SMILES

O=C(C1=NC2=C(C(C3=C(F)C=C(OC)C=C3)=C1)CCC(C)(C)O2)N
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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mG2N001 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mG2N0012760515-88-4mGluRSrcMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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