Methylprednisolone-d₇ (Synonyms: U 7532-d₇)

Cat. No.: HY-B0260S3: FAQs
Data Sheet SDS COA Handling Instructions

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Methylprednisolone-d₇ is deuterium labeled Methylprednisolone. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels[3].

For research use only. We do not sell to patients.

Methylprednisolone-d<sub>7</sub> Chemical Structure

Methylprednisolone-d₇ Chemical Structure

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1 mg	USD 2350	Ask For Quote & Lead Time

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Other Forms of Methylprednisolone-d₇:

Methylprednisolone In-stock

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Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

381.51

Formula

C₂₂H₂₃D₇O₅

Unlabeled Cas

83-43-2

Appearance

Solid

Color

White to off-white

SMILES

O=C1C([2H])=C[C@@]2([C@]3([C@]([2H])(C([2H])([C@@]4([C@@](C(CO)=O)(CC[C@]4([C@@]3(C[C@@]([2H])(C2=C1[2H])C)[H])[H])O)C)[2H])O)[2H])C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (327.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.26 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6212 mL	13.1058 mL	26.2116 mL
5 mM	0.5242 mL	2.6212 mL	5.2423 mL
10 mM	0.2621 mL	1.3106 mL	2.6212 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (279 KB) SDS (251 KB)

COA (257 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Strupp, M., et al., Methylprednisolone, valacyclovir, or the combination for vestibular neuritis. N Engl J Med, 2004. 351(4): p. 354-61. [Content Brief]

[3]. Bracken, M.B., et al., A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med, 1990. 322(20): p. 1405-11. [Content Brief]

[4]. Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16(13):2382-2391.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6212 mL	13.1058 mL	26.2116 mL	65.5291 mL
	5 mM	0.5242 mL	2.6212 mL	5.2423 mL	13.1058 mL
	10 mM	0.2621 mL	1.3106 mL	2.6212 mL	6.5529 mL
	15 mM	0.1747 mL	0.8737 mL	1.7474 mL	4.3686 mL
	20 mM	0.1311 mL	0.6553 mL	1.3106 mL	3.2765 mL
	25 mM	0.1048 mL	0.5242 mL	1.0485 mL	2.6212 mL
	30 mM	0.0874 mL	0.4369 mL	0.8737 mL	2.1843 mL
	40 mM	0.0655 mL	0.3276 mL	0.6553 mL	1.6382 mL
	50 mM	0.0524 mL	0.2621 mL	0.5242 mL	1.3106 mL
	60 mM	0.0437 mL	0.2184 mL	0.4369 mL	1.0922 mL
	80 mM	0.0328 mL	0.1638 mL	0.3276 mL	0.8191 mL
	100 mM	0.0262 mL	0.1311 mL	0.2621 mL	0.6553 mL

Methylprednisolone-d₇ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methylprednisolone-d₇U 7532-d₇Glucocorticoid ReceptorAutophagySARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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Methylprednisolone-d7 (Synonyms: U 7532-d7)

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