1. Academic Validation
  2. Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro

Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro

  • Mol Cell Biochem. 2009 Oct;330(1-2):181-5. doi: 10.1007/s11010-009-0131-4.
Xu Sun 1 Xiao-Dong Zhang Gang Cheng You-Hong Hu He-Yao Wang
Affiliations

Affiliation

  • 1 Shanghai Institute of Materia Medica, Chinese Academy of Science, 201203, Shanghai, China.
Abstract

Hepatic stellate cells (HSCs) play an important role in the development of hepatic fibrosis. Heat shock protein 90 (HSP90) is essential for the maturation and activity of a varied group of proteins involved in signal transduction and cell cycle regulation. In this study, we found that two HSP90 inhibitors, VER-49009 and its analog VER-49009M, inhibited the proliferation of hepatic stellate cell line CFSC cells, and both of them induced G2 phase arrest in CFSC cells. Akt expression was decreased by the treatment of HSP90 inhibitors in CFSC cells. Based on these findings, we propose that the inhibition of HSP90 might be a rational approach in the prevention of liver fibrosis.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-15986
    99.45%, HSP Inhibitor
    HSP