2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Levofloxacin N-oxide

Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria.

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Levofloxacin N-oxide Chemical Structure

Levofloxacin N-oxide Chemical Structure

CAS No. : 117678-38-3

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Based on 1 publication(s) in Google Scholar

Levofloxacin N-oxide Related Antibodies

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Description

Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria[1][2].

Molecular Weight

377.37

Formula

C18H20FN3O5
CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CC[N+](C)([O-])CC4)C(F)=CC1=C23)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (132.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6499 mL 13.2496 mL 26.4992 mL
5 mM 0.5300 mL 2.6499 mL 5.2998 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6499 mL 13.2496 mL 26.4992 mL 66.2480 mL
5 mM 0.5300 mL 2.6499 mL 5.2998 mL 13.2496 mL
10 mM 0.2650 mL 1.3250 mL 2.6499 mL 6.6248 mL
15 mM 0.1767 mL 0.8833 mL 1.7666 mL 4.4165 mL
20 mM 0.1325 mL 0.6625 mL 1.3250 mL 3.3124 mL
25 mM 0.1060 mL 0.5300 mL 1.0600 mL 2.6499 mL
30 mM 0.0883 mL 0.4417 mL 0.8833 mL 2.2083 mL
40 mM 0.0662 mL 0.3312 mL 0.6625 mL 1.6562 mL
50 mM 0.0530 mL 0.2650 mL 0.5300 mL 1.3250 mL
60 mM 0.0442 mL 0.2208 mL 0.4417 mL 1.1041 mL
80 mM 0.0331 mL 0.1656 mL 0.3312 mL 0.8281 mL
100 mM 0.0265 mL 0.1325 mL 0.2650 mL 0.6625 mL
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Levofloxacin N-oxide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levofloxacin N-oxide117678-38-3Drug Metaboliteminor metaboliteLevofloxacingenotoxic risksbacteriaInhibitorinhibitorinhibit

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