2. Metabolic Enzyme/Protease
  3. Drug Metabolite Endogenous Metabolite
  4. Leukotriene D4-d5

Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.

For research use only. We do not sell to patients.

Leukotriene D4-d<sub>5</sub> Chemical Structure

Leukotriene D4-d5 Chemical Structure

CAS No. : 1240398-17-7

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Solvent
25μg（199.33 μM * 250 μL in Ethanol） USD 1100 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Leukotriene D4-d5:

Leukotriene D4-d5 Related Antibodies

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Description

Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Leukotriene D4-d5 Related Antibodies
Molecular Weight

501.69

Formula

C25H35D5N2O6S
CAS No.
Unlabeled CAS

73836-78-9
Appearance

Liquid

Color

Colorless to light yellow

SMILES

N[C@@H](CS[C@H](/C=C/C=C/C=C\C/C=C\CCCC([2H])(C([2H])([2H])[2H])[2H])[C@H](CCCC(O)=O)O)C(NCC(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

DMF : ≥ 50 mg/mL (99.66 mM)

DMSO : ≥ 50 mg/mL (99.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 1 mg/mL (1.99 mM)

*"≥" means soluble, but saturation unknown.

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Purity & Documentation

Purity: ≥98.0%

COA (243 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMF / DMSO 1 mM 1.9933 mL 9.9663 mL 19.9326 mL 49.8316 mL
DMF / DMSO 5 mM 0.3987 mL 1.9933 mL 3.9865 mL 9.9663 mL
10 mM 0.1993 mL 0.9966 mL 1.9933 mL 4.9832 mL
15 mM 0.1329 mL 0.6644 mL 1.3288 mL 3.3221 mL
20 mM 0.0997 mL 0.4983 mL 0.9966 mL 2.4916 mL
25 mM 0.0797 mL 0.3987 mL 0.7973 mL 1.9933 mL
30 mM 0.0664 mL 0.3322 mL 0.6644 mL 1.6611 mL
40 mM 0.0498 mL 0.2492 mL 0.4983 mL 1.2458 mL
50 mM 0.0399 mL 0.1993 mL 0.3987 mL 0.9966 mL
60 mM 0.0332 mL 0.1661 mL 0.3322 mL 0.8305 mL
80 mM 0.0249 mL 0.1246 mL 0.2492 mL 0.6229 mL
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Leukotriene D4-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leukotriene D4-d51240398-17-7Drug MetaboliteEndogenous MetaboliteInhibitorinhibitorinhibit

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