2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Glucocorticoid Receptor Endogenous Metabolite
  4. Hydrocortisone-d4

Hydrocortisone-d4  (Synonyms: Cortisol-d4)

Cat. No.: HY-N0583S2 Purity: ≥98.0%
COA Handling Instructions

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Hydrocortisone-d4 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

For research use only. We do not sell to patients.

Hydrocortisone-d<sub>4</sub> Chemical Structure

Hydrocortisone-d4 Chemical Structure

CAS No. : 73565-87-4

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1 mg USD 680 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Hydrocortisone-d4:

Hydrocortisone-d4 Related Antibodies

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  • Purity & Documentation

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Description

Hydrocortisone-d4 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydrocortisone-d4 Related Antibodies
Molecular Weight

366.48

Formula

C21H26D4O5
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

C[C@@]12[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([2H])[C@@]([2H])(O)C2([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 30 mg/mL (81.86 mM)

DMSO : ≥ 20 mg/mL (54.57 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : ≥ 2 mg/mL (5.46 mM)

DMF:PBS (pH 7.2) (1:4) : ≥ 0.2 mg/mL (0.55 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7287 mL 13.6433 mL 27.2866 mL
5 mM 0.5457 mL 2.7287 mL 5.4573 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO / DMF 1 mM 2.7287 mL 13.6433 mL 27.2866 mL 68.2165 mL
5 mM 0.5457 mL 2.7287 mL 5.4573 mL 13.6433 mL
DMSO / DMF 10 mM 0.2729 mL 1.3643 mL 2.7287 mL 6.8217 mL
15 mM 0.1819 mL 0.9096 mL 1.8191 mL 4.5478 mL
20 mM 0.1364 mL 0.6822 mL 1.3643 mL 3.4108 mL
25 mM 0.1091 mL 0.5457 mL 1.0915 mL 2.7287 mL
30 mM 0.0910 mL 0.4548 mL 0.9096 mL 2.2739 mL
40 mM 0.0682 mL 0.3411 mL 0.6822 mL 1.7054 mL
50 mM 0.0546 mL 0.2729 mL 0.5457 mL 1.3643 mL
DMF 60 mM 0.0455 mL 0.2274 mL 0.4548 mL 1.1369 mL
80 mM 0.0341 mL 0.1705 mL 0.3411 mL 0.8527 mL
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Hydrocortisone-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrocortisone-d473565-87-4Cortisol-d4Glucocorticoid ReceptorEndogenous MetaboliteInhibitorinhibitorinhibit

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