2. Stem Cell/Wnt TGF-beta/Smad Membrane Transporter/Ion Channel
  3. TGF-beta/Smad Potassium Channel
  4. Hydrochlorothiazid-d2

Hydrochlorothiazid-d2  (Synonyms: HCTZ-d2)

Cat. No.: HY-B0252S Purity: 98.89%
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Hydrochlorothiazid-d2 is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].

For research use only. We do not sell to patients.

Hydrochlorothiazid-d<sub>2</sub> Chemical Structure

Hydrochlorothiazid-d2 Chemical Structure

CAS No. : 1219798-89-6

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1 mg USD 80 In-stock
5 mg USD 230 In-stock
10 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Hydrochlorothiazid-d2:

Hydrochlorothiazid-d2 Related Antibodies

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Description

Hydrochlorothiazid-d2 is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydrochlorothiazid-d2 Related Antibodies
Molecular Weight

299.75

Formula

C7H6D2ClN3O4S2
CAS No.
Unlabeled CAS

58-93-5
Appearance

Solid

Color

White to off-white

SMILES

O=S1(C2=CC(S(N)(=O)=O)=C(Cl)C=C2NC([2H])([2H])N1)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (166.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3361 mL 16.6806 mL 33.3611 mL
5 mM 0.6672 mL 3.3361 mL 6.6722 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3361 mL 16.6806 mL 33.3611 mL 83.4028 mL
5 mM 0.6672 mL 3.3361 mL 6.6722 mL 16.6806 mL
10 mM 0.3336 mL 1.6681 mL 3.3361 mL 8.3403 mL
15 mM 0.2224 mL 1.1120 mL 2.2241 mL 5.5602 mL
20 mM 0.1668 mL 0.8340 mL 1.6681 mL 4.1701 mL
25 mM 0.1334 mL 0.6672 mL 1.3344 mL 3.3361 mL
30 mM 0.1112 mL 0.5560 mL 1.1120 mL 2.7801 mL
40 mM 0.0834 mL 0.4170 mL 0.8340 mL 2.0851 mL
50 mM 0.0667 mL 0.3336 mL 0.6672 mL 1.6681 mL
60 mM 0.0556 mL 0.2780 mL 0.5560 mL 1.3900 mL
80 mM 0.0417 mL 0.2085 mL 0.4170 mL 1.0425 mL
100 mM 0.0334 mL 0.1668 mL 0.3336 mL 0.8340 mL
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Hydrochlorothiazid-d2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrochlorothiazid-d21219798-89-6HCTZ-d2TGF-beta/SmadPotassium ChannelTransforming growth factor betaKcsAInhibitorinhibitorinhibit

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