2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Apoptosis
  3. RAR/RXR Apoptosis
  4. HX630

HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research.

For research use only. We do not sell to patients.

HX630 Chemical Structure

HX630 Chemical Structure

CAS No. : 188844-52-2

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Based on 1 publication(s) in Google Scholar

HX630 Related Antibodies

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Description

HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research[1].

In Vitro

HX630 (0.1-10 μM, 96 h) can dose-dependently inhibit cell proliferation and induce apoptosis of AtT20 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HX630 Related Antibodies

Cell Viability Assay[1]

Cell Line: AtT20 cells
Concentration: 0.1, 1, 5, 10 μM
Incubation Time: 96 h
Result: Significantly inhibited AtT20 cell proliferation at 10 μM.
Decreased Pomc mRNA expression and ACTH secretion in a dose-dependent manner.
In Vivo

HX630 (5 mg/kg, intraperitoneal injection, 3 times a week for 3 weeks) can reduce tumor growth in BALB/c-nu mouse model infected with AtT20 cells[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c-nu mice (nu/nu) with AtT20 cells[1]
Dosage: 5 mg/kg
Administration: i.p., 3 times a week for 3 weeks
Result: Significantly reduced tumor volume and Pomc mRNA expression in tumor cells, but body weight and plasma ACTH levels were not significantly different.
Molecular Weight

441.58

Formula

C28H27NO2S
CAS No.
Unlabeled Cas

SMILES

O=C(O)C1=CC=C(C(C2=C3)=NC4=CC=CC=C4SC2=CC5=C3C(C)(C)CCC5(C)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HX630 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HX630188844-52-2HX 630HX-630RAR/RXRApoptosisRetinoic acid receptorsRetinoid X receptorsretinoic acid X receptorapoptosisanti-tumorCushing's diseaseInhibitorinhibitorinhibit

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HY-108520
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