2. Metabolic Enzyme/Protease Autophagy Membrane Transporter/Ion Channel
  3. Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein
  4. Glyburide-d3

Glyburide-d3  (Synonyms: Glyburide-d3)

Cat. No.: HY-15206S1 Purity: ≥98.0%
COA Handling Instructions

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Glyburide-d3 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

For research use only. We do not sell to patients.

Glyburide-d<sub>3</sub> Chemical Structure

Glyburide-d3 Chemical Structure

CAS No. : 1219803-02-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Glyburide-d3:

Glyburide-d3 Related Antibodies

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Description

Glyburide-d3 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glyburide-d3 Related Antibodies
Molecular Weight

497.02

Formula

C23H25D3ClN3O5S
CAS No.
Unlabeled Cas

10238-21-8
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCC1=CC=C(S(=O)(NC(NC2CCCCC2)=O)=O)C=C1)C3=CC(Cl)=CC=C3OC([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (503.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.20 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0120 mL 10.0600 mL 20.1199 mL
5 mM 0.4024 mL 2.0120 mL 4.0240 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0120 mL 10.0600 mL 20.1199 mL 50.2998 mL
5 mM 0.4024 mL 2.0120 mL 4.0240 mL 10.0600 mL
10 mM 0.2012 mL 1.0060 mL 2.0120 mL 5.0300 mL
15 mM 0.1341 mL 0.6707 mL 1.3413 mL 3.3533 mL
20 mM 0.1006 mL 0.5030 mL 1.0060 mL 2.5150 mL
25 mM 0.0805 mL 0.4024 mL 0.8048 mL 2.0120 mL
30 mM 0.0671 mL 0.3353 mL 0.6707 mL 1.6767 mL
40 mM 0.0503 mL 0.2515 mL 0.5030 mL 1.2575 mL
50 mM 0.0402 mL 0.2012 mL 0.4024 mL 1.0060 mL
60 mM 0.0335 mL 0.1677 mL 0.3353 mL 0.8383 mL
80 mM 0.0251 mL 0.1257 mL 0.2515 mL 0.6287 mL
100 mM 0.0201 mL 0.1006 mL 0.2012 mL 0.5030 mL
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Glyburide-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glyburide-d31219803-02-7Potassium ChannelMitochondrial MetabolismAutophagyCFTRP-glycoproteinKcsACystic fibrosis transmembrane conductance regulatorP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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