2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Gliclazide-d4

Gliclazide-d4 (S1702 D4) is the deuterium labeled Gliclazide. Gliclazide (S1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Gliclazide is used as an antidiabetic[1].

For research use only. We do not sell to patients.

Gliclazide-d<sub>4</sub> Chemical Structure

Gliclazide-d4 Chemical Structure

CAS No. : 1185039-30-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Gliclazide-d4:

Gliclazide-d4 Related Antibodies

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Description

Gliclazide-d4 (S1702 D4) is the deuterium labeled Gliclazide. Gliclazide (S1702) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Gliclazide is used as an antidiabetic[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gliclazide-d4 Related Antibodies
Molecular Weight

327.44

Formula

C15H17D4N3O3S
CAS No.
Unlabeled CAS

21187-98-4
Appearance

Solid

Color

White to off-white

SMILES

O=S(NC(NN1CC2C(CCC2)C1)=O)(C3=C([2H])C([2H])=C(C([2H])=C3[2H])C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (305.40 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.31 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0540 mL 15.2700 mL 30.5399 mL
5 mM 0.6108 mL 3.0540 mL 6.1080 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0540 mL 15.2700 mL 30.5399 mL 76.3499 mL
5 mM 0.6108 mL 3.0540 mL 6.1080 mL 15.2700 mL
10 mM 0.3054 mL 1.5270 mL 3.0540 mL 7.6350 mL
15 mM 0.2036 mL 1.0180 mL 2.0360 mL 5.0900 mL
20 mM 0.1527 mL 0.7635 mL 1.5270 mL 3.8175 mL
25 mM 0.1222 mL 0.6108 mL 1.2216 mL 3.0540 mL
30 mM 0.1018 mL 0.5090 mL 1.0180 mL 2.5450 mL
40 mM 0.0763 mL 0.3817 mL 0.7635 mL 1.9087 mL
50 mM 0.0611 mL 0.3054 mL 0.6108 mL 1.5270 mL
60 mM 0.0509 mL 0.2545 mL 0.5090 mL 1.2725 mL
80 mM 0.0382 mL 0.1909 mL 0.3817 mL 0.9544 mL
100 mM 0.0305 mL 0.1527 mL 0.3054 mL 0.7635 mL
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Gliclazide-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gliclazide-d41185039-30-8Potassium ChannelKcsAInhibitorinhibitorinhibit

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