MMP15 - matrix metallopeptidase 15 Gene

Homo sapiens

Also known as MMP-15; MT2MMP; MTMMP2; SMCP-2; MT2-MMP

Gene ID: 4324 | Gene type: protein coding

About MMP15

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,025,754-58,046,901 (from NCBI)

This gene has 2 transcripts (splice variants), 274 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in thyroid (RPKM 28.2), placenta (RPKM 20.0) and 22 other tissues.

Summary

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in Cancer progression. [provided by RefSeq, Jan 2016]

MMP15 Products(1)

mRNA	Protein	Name
NM_002428.4	NP_002419.1	matrix metalloproteinase-15 preproprotein

MMP15 Protein Structure

PG_binding_1

Peptidase_M10

Hemopexin

DUF3377

0
200
400
600
669 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-15

MT-MMP 2

Related Diseases

Diseases

Alias

Supraglottis Cancer

Malignant Tumor Of Supraglottis	Supraglottis
Ca Larynx - Supraglottis	Malignant Neoplasm Of Extrinsic Larynx
Malignant Neoplasm Of Supraglottis	Malignant Supraglottic Tumor
Neoplasm Of Supraglottis

Winchester Syndrome

WNCHRS	Winchester Disease
Winchester-Grossman Syndrome

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Asymptomatic Dengue

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08531	MMP15 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MMP15	VGNC	VGNC:74893
Mus musculus	MMP15	MGD	MGI:109320
Rattus norvegicus	MMP15	RGD	RGD:1308937
Canis familiaris	MMP15	VGNC	VGNC:49926
Felis catus	MMP15	VGNC	VGNC:68283
Bos taurus	MMP15	VGNC	VGNC:31520

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