2. Gene
  3. GDI2 - GDP dissociation inhibitor 2 Gene

GDI2 - GDP dissociation inhibitor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RABGDIB; HEL-S-46e

Gene ID: 2665 | Gene type: protein coding

About GDI2

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,765,223-5,813,434 (from NCBI)

This gene has 9 transcripts (splice variants), 252 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 104.1), appendix (RPKM 84.4) and 25 other tissues.

Summary

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the Ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GDI2 Products(2)

mRNA Protein Name
NM_001115156.2 NP_001108628.1 rab GDP dissociation inhibitor beta isoform 2
NM_001494.4 NP_001485.2 rab GDP dissociation inhibitor beta isoform 1

GDI2 Protein Structure

GDI

GDI: GDP dissociation inhibitor (1 - 437)

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  • 445 a.a.
Protein Preferred Names Protein Names

rab GDP dissociation inhibitor beta

GDI-2

Recombinant GDI2 Proteins

Cat. No. Product Name Accession Purity
HY-P71737 GDI2 Protein, Human (P.pastoris, His) P50395 (1M-445D) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156242 BQZ-485 Inducer / Unkown
HY-156243 GDI2-IN-1 / Unkown
HY-156244 PROTAC GDI2 Degrader-1 / Unkown
HY-RS05360 GDI2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GDI2 MGD MGI:99845
Rattus norvegicus GDI2 RGD RGD:61802
Bos taurus GDI2 VGNC VGNC:29308
Canis familiaris GDI2 VGNC VGNC:41165
Felis catus GDI2 VGNC VGNC:62507
Macaca mulatta GDI2 VGNC VGNC:72911
Others GDI2 NCBI