2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Autophagy
  3. EGFR Autophagy
  4. Gefitinib-d8

Gefitinib-d8  (Synonyms: ZD1839-d8)

Cat. No.: HY-50895S Purity: 98.42%
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Gefitinib-d8 is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].

For research use only. We do not sell to patients.

Gefitinib-d<sub>8</sub> Chemical Structure

Gefitinib-d8 Chemical Structure

CAS No. : 857091-32-8

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1 mg USD 650 In-stock
5 mg USD 1820 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Gefitinib-d8 is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells[1][2].

IC50 & Target

IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)[1]
Molecular Weight

454.95

Formula

C22H16D8ClFN4O3
CAS No.
Unlabeled Cas

184475-35-2
Appearance

Solid

Color

White to off-white

SMILES

[2H]C1([2H])OC([2H])([2H])C([2H])([2H])N(CCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)C1([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (274.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1980 mL 10.9902 mL 21.9804 mL
5 mM 0.4396 mL 2.1980 mL 4.3961 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.42%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1980 mL 10.9902 mL 21.9804 mL 54.9511 mL
5 mM 0.4396 mL 2.1980 mL 4.3961 mL 10.9902 mL
10 mM 0.2198 mL 1.0990 mL 2.1980 mL 5.4951 mL
15 mM 0.1465 mL 0.7327 mL 1.4654 mL 3.6634 mL
20 mM 0.1099 mL 0.5495 mL 1.0990 mL 2.7476 mL
25 mM 0.0879 mL 0.4396 mL 0.8792 mL 2.1980 mL
30 mM 0.0733 mL 0.3663 mL 0.7327 mL 1.8317 mL
40 mM 0.0550 mL 0.2748 mL 0.5495 mL 1.3738 mL
50 mM 0.0440 mL 0.2198 mL 0.4396 mL 1.0990 mL
60 mM 0.0366 mL 0.1832 mL 0.3663 mL 0.9159 mL
80 mM 0.0275 mL 0.1374 mL 0.2748 mL 0.6869 mL
100 mM 0.0220 mL 0.1099 mL 0.2198 mL 0.5495 mL
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Gefitinib-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gefitinib-d8857091-32-8ZD1839-d8EGFRAutophagyEpidermal growth factor receptorErbB-1HER1DeuteriumlabeledGefitinibInhibitorinhibitorinhibit

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