2. Anti-infection
  3. Fungal Antibiotic
  4. Fluconazole-d4

Fluconazole-d4  (Synonyms: UK-49858-d4)

Cat. No.: HY-B0101S Purity: 99.66%
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Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1].

For research use only. We do not sell to patients.

Fluconazole-d<sub>4</sub> Chemical Structure

Fluconazole-d4 Chemical Structure

CAS No. : 1124197-58-5

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1 mg USD 430 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Fluconazole-d4:

Fluconazole-d4 Related Antibodies

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Description

Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fluconazole-d4 Related Antibodies
Molecular Weight

310.30

Formula

C13H8D4F2N6O
CAS No.
Unlabeled CAS

86386-73-4
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC(F)=C(C=C1)C(O)(C([2H])(N2C=NC=N2)[2H])C([2H])(N3C=NC=N3)[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (322.27 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 2 mg/mL (6.45 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2227 mL 16.1134 mL 32.2269 mL
5 mM 0.6445 mL 3.2227 mL 6.4454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.2227 mL 16.1134 mL 32.2269 mL 80.5672 mL
5 mM 0.6445 mL 3.2227 mL 6.4454 mL 16.1134 mL
DMSO 10 mM 0.3223 mL 1.6113 mL 3.2227 mL 8.0567 mL
15 mM 0.2148 mL 1.0742 mL 2.1485 mL 5.3711 mL
20 mM 0.1611 mL 0.8057 mL 1.6113 mL 4.0284 mL
25 mM 0.1289 mL 0.6445 mL 1.2891 mL 3.2227 mL
30 mM 0.1074 mL 0.5371 mL 1.0742 mL 2.6856 mL
40 mM 0.0806 mL 0.4028 mL 0.8057 mL 2.0142 mL
50 mM 0.0645 mL 0.3223 mL 0.6445 mL 1.6113 mL
60 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.3428 mL
80 mM 0.0403 mL 0.2014 mL 0.4028 mL 1.0071 mL
100 mM 0.0322 mL 0.1611 mL 0.3223 mL 0.8057 mL
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Fluconazole-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluconazole-d41124197-58-5UK-49858-d4FungalAntibioticInhibitorinhibitorinhibit

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