2. Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Estrogen Receptor/ERR Endogenous Metabolite
  4. Estrone-d4

Estrone-d4  (Synonyms: E1-d4; Oestrone-d4)

Cat. No.: HY-B0234S2 Purity: ≥99.0%
COA Handling Instructions

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Estrone-d4 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

For research use only. We do not sell to patients.

Estrone-d<sub>4</sub> Chemical Structure

Estrone-d4 Chemical Structure

CAS No. : 53866-34-5

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1 mg USD 511 In-stock
5 mg USD 1125 In-stock
10 mg USD 1800 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Estrone-d4:

Estrone-d4 Related Antibodies

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Description

Estrone-d4 is the deuterium labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Estrone-d4 Related Antibodies
Molecular Weight

274.39

Formula

C18H18D4O2
CAS No.
Unlabeled CAS

53-16-7
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC([2H])([2H])C2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC([2H])=C(O)C([2H])=C4CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (91.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.36 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6444 mL 18.2222 mL 36.4445 mL
5 mM 0.7289 mL 3.6444 mL 7.2889 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6444 mL 18.2222 mL 36.4445 mL 91.1112 mL
5 mM 0.7289 mL 3.6444 mL 7.2889 mL 18.2222 mL
10 mM 0.3644 mL 1.8222 mL 3.6444 mL 9.1111 mL
15 mM 0.2430 mL 1.2148 mL 2.4296 mL 6.0741 mL
20 mM 0.1822 mL 0.9111 mL 1.8222 mL 4.5556 mL
25 mM 0.1458 mL 0.7289 mL 1.4578 mL 3.6444 mL
30 mM 0.1215 mL 0.6074 mL 1.2148 mL 3.0370 mL
40 mM 0.0911 mL 0.4556 mL 0.9111 mL 2.2778 mL
50 mM 0.0729 mL 0.3644 mL 0.7289 mL 1.8222 mL
60 mM 0.0607 mL 0.3037 mL 0.6074 mL 1.5185 mL
80 mM 0.0456 mL 0.2278 mL 0.4556 mL 1.1389 mL
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Estrone-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Estrone-d453866-34-5E1-d4Oestrone-d4Estrogen Receptor/ERREndogenous MetaboliteInhibitorinhibitorinhibit

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