ERK1/2 inhibitor 9

Cat. No.: HY-153738 Purity: 95.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor. ERK1/2 inhibitor 9 shows sub-micromolar activity in cells (A375 GI50=0.47 μM). ERK1/2 inhibitor 9 causes the downregulation of phospho-ERK1/2. ERK1/2 inhibitor 9 tagged trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine tagged Thalidomide) can form the corresponding ERK-CLIPTAC to elicit degradation of ERK1/2.

For research use only. We do not sell to patients.

ERK1/2 inhibitor 9 Chemical Structure

CAS No. : 2169302-75-2

Size	Price	Stock	Quantity
1 mg	USD 1460	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 4800	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

ERK1

ERK2

Molecular Weight

586.08

Formula

C₃₁H₃₂ClN₇O₃

CAS No.

2169302-75-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCCC#CC1=NC=CC(NC2=NC=C(C(NC3=C(NC(C=C)=O)C=CC=C3)=N2)Cl)=C1)OC4CC/C=C\CCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (85.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7063 mL	8.5313 mL	17.0625 mL
5 mM	0.3413 mL	1.7063 mL	3.4125 mL
10 mM	0.1706 mL	0.8531 mL	1.7063 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.91%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (245 KB) HNMR (273 KB) RP-HPLC (265 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Honorine Lebraud, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2(12):927-934. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7063 mL	8.5313 mL	17.0625 mL	42.6563 mL
	5 mM	0.3413 mL	1.7063 mL	3.4125 mL	8.5313 mL
	10 mM	0.1706 mL	0.8531 mL	1.7063 mL	4.2656 mL
	15 mM	0.1138 mL	0.5688 mL	1.1375 mL	2.8438 mL
	20 mM	0.0853 mL	0.4266 mL	0.8531 mL	2.1328 mL
	25 mM	0.0683 mL	0.3413 mL	0.6825 mL	1.7063 mL
	30 mM	0.0569 mL	0.2844 mL	0.5688 mL	1.4219 mL
	40 mM	0.0427 mL	0.2133 mL	0.4266 mL	1.0664 mL
	50 mM	0.0341 mL	0.1706 mL	0.3413 mL	0.8531 mL
	60 mM	0.0284 mL	0.1422 mL	0.2844 mL	0.7109 mL
	80 mM	0.0213 mL	0.1066 mL	0.2133 mL	0.5332 mL