2. Others Anti-infection Cell Cycle/DNA Damage Epigenetics
  3. Isotope-Labeled Compounds Bacterial DNA/RNA Synthesis MicroRNA Antibiotic
  4. Enoxacin-d8 hydrochloride

Enoxacin-d8 (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing[1][2][3][4].

For research use only. We do not sell to patients.

Enoxacin-d<sub>8</sub> hydrochloride Chemical Structure

Enoxacin-d8 hydrochloride Chemical Structure

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1 mg USD 420 In-stock
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Enoxacin-d8 hydrochloride Related Antibodies

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Description

Enoxacin-d8 (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enoxacin-d8 hydrochloride Related Antibodies
Molecular Weight

364.83

Formula

C15H10D8ClFN4O3
Unlabeled CAS

74011-58-8
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(CC)C2=NC(N3C([2H])([2H])C([2H])([2H])NC([2H])([2H])C3([2H])[2H])=C(C=C2C1=O)F)O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 15 mg/mL (41.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

PBS (pH 7.2) : ≥ 10 mg/mL (27.41 mM)

DMF : ≥ 0.1 mg/mL (0.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7410 mL 13.7050 mL 27.4100 mL
5 mM 0.5482 mL 2.7410 mL 5.4820 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) / DMSO 1 mM 2.7410 mL 13.7050 mL 27.4100 mL 68.5251 mL
5 mM 0.5482 mL 2.7410 mL 5.4820 mL 13.7050 mL
10 mM 0.2741 mL 1.3705 mL 2.7410 mL 6.8525 mL
15 mM 0.1827 mL 0.9137 mL 1.8273 mL 4.5683 mL
20 mM 0.1371 mL 0.6853 mL 1.3705 mL 3.4263 mL
25 mM 0.1096 mL 0.5482 mL 1.0964 mL 2.7410 mL
DMSO 30 mM 0.0914 mL 0.4568 mL 0.9137 mL 2.2842 mL
40 mM 0.0685 mL 0.3426 mL 0.6853 mL 1.7131 mL
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Enoxacin-d8 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enoxacin-d8Isotope-Labeled CompoundsBacterialDNA/RNA SynthesisMicroRNAAntibioticmiRNAInhibitorinhibitorinhibit

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