2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Metabolic Enzyme/Protease
  3. Histamine Receptor Cytochrome P450
  4. Doxepin-d3 hydrochloride

Doxepin-d3 (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].

For research use only. We do not sell to patients.

Doxepin-d<sub>3</sub> hydrochloride Chemical Structure

Doxepin-d3 hydrochloride Chemical Structure

CAS No. : 347840-07-7

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1 mg USD 150 In-stock
5 mg USD 370 In-stock
10 mg USD 640 In-stock
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Based on 1 publication(s) in Google Scholar

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Doxepin-d3 hydrochloride Related Antibodies

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Description

Doxepin-d3 (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].

IC50 & Target

Histamine receptor H1; CYP450 2C19 and CYP450 1A2[2]
Molecular Weight

318.86

Formula

C19H19D3ClNO
CAS No.
Unlabeled CAS

1229-29-4
Appearance

Solid

Color

Off-white to light yellow

SMILES

[2H]C(N(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C\13)([2H])[2H].[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (313.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (156.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1362 mL 15.6809 mL 31.3617 mL
5 mM 0.6272 mL 3.1362 mL 6.2723 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.1362 mL 15.6809 mL 31.3617 mL 78.4043 mL
5 mM 0.6272 mL 3.1362 mL 6.2723 mL 15.6809 mL
10 mM 0.3136 mL 1.5681 mL 3.1362 mL 7.8404 mL
15 mM 0.2091 mL 1.0454 mL 2.0908 mL 5.2270 mL
20 mM 0.1568 mL 0.7840 mL 1.5681 mL 3.9202 mL
25 mM 0.1254 mL 0.6272 mL 1.2545 mL 3.1362 mL
30 mM 0.1045 mL 0.5227 mL 1.0454 mL 2.6135 mL
40 mM 0.0784 mL 0.3920 mL 0.7840 mL 1.9601 mL
50 mM 0.0627 mL 0.3136 mL 0.6272 mL 1.5681 mL
60 mM 0.0523 mL 0.2613 mL 0.5227 mL 1.3067 mL
80 mM 0.0392 mL 0.1960 mL 0.3920 mL 0.9801 mL
100 mM 0.0314 mL 0.1568 mL 0.3136 mL 0.7840 mL
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Doxepin-d3 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Doxepin-d3347840-07-7Histamine ReceptorCytochrome P450CYPsDeuteriumlabeledDoxepintricyclicantidepressantsedativeCYP450 2C19CYP450 1A2.Inhibitorinhibitorinhibit

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