Diphenhydramine-d₆ hydrochloride

Name: Diphenhydramine-d 6 hydrochloride
Brand: MedChemExpress
SKU: HY-B0303AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0303AS Purity: 98.83%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Diphenhydramine-d₆ (hydrochloride) is the deuterium labeled Diphenhydramine hydrochloride. Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB)[1][2].

For research use only. We do not sell to patients.

Diphenhydramine-d<sub>6</sub> hydrochloride Chemical Structure

Diphenhydramine-d₆ hydrochloride Chemical Structure

CAS No. : 1189986-72-8

Size	Price	Stock	Quantity
1 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Diphenhydramine-d₆ hydrochloride:

Diphenhydramine hydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

H₁ Receptor

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.85

Formula

C₁₇H₁₆D₆ClNO

CAS No.

1189986-72-8

Unlabeled Cas

147-24-0

Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])N(C([2H])([2H])[2H])CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (335.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (335.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3574 mL	16.7870 mL	33.5739 mL
5 mM	0.6715 mL	3.3574 mL	6.7148 mL
10 mM	0.3357 mL	1.6787 mL	3.3574 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.83%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) HNMR (116 KB) RP-HPLC (73 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Simons FE. H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994;10(5):350-380. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H2O	1 mM	3.3574 mL	16.7870 mL	33.5739 mL	83.9349 mL
	5 mM	0.6715 mL	3.3574 mL	6.7148 mL	16.7870 mL
	10 mM	0.3357 mL	1.6787 mL	3.3574 mL	8.3935 mL
	15 mM	0.2238 mL	1.1191 mL	2.2383 mL	5.5957 mL
	20 mM	0.1679 mL	0.8393 mL	1.6787 mL	4.1967 mL
	25 mM	0.1343 mL	0.6715 mL	1.3430 mL	3.3574 mL
	30 mM	0.1119 mL	0.5596 mL	1.1191 mL	2.7978 mL
	40 mM	0.0839 mL	0.4197 mL	0.8393 mL	2.0984 mL
	50 mM	0.0671 mL	0.3357 mL	0.6715 mL	1.6787 mL
	60 mM	0.0560 mL	0.2798 mL	0.5596 mL	1.3989 mL
	80 mM	0.0420 mL	0.2098 mL	0.4197 mL	1.0492 mL
	100 mM	0.0336 mL	0.1679 mL	0.3357 mL	0.8393 mL