Dimethindene

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Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K⁺ currents.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Dimethindene maleate) that retains the same biological activity.

For research use only. We do not sell to patients.

Dimethindene Chemical Structure

CAS No. : 5636-83-9

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Other In-stock Forms of Dimethindene:

(S)-(+)-Dimethindene maleate Dimethindene maleate

Other Forms of Dimethindene:

(S)-(+)-Dimethindene maleate In-stock
Dimethindene maleate In-stock

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Biological Activity
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Description

Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K⁺ currents^[1]^[2].

In Vitro

Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K⁺ currents with an IC₅₀ value of 29.5 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice with skin WH^[1]
Dosage:	0.25 mg
Administration:	intraperitoneal injection; once
Result:	Delayed skin wound closure as compared to vehicle treated mice.

Molecular Weight

292.42

Formula

C₂₀H₂₄N₂

CAS No.

5636-83-9

Unlabeled CAS

SMILES

CC(C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Weller K, et, al. Mast cells are required for normal healing of skin wounds in mice. FASEB J. 2006 Nov;20(13):2366-8. [Content Brief]

[2]. Sakuta H. Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102. [Content Brief]

Dimethindene Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethindene5636-83-9Histamine ReceptorPotassium ChannelEndogenous MetaboliteKcsAcutaneous wound healingK+ currentsfollicle-enclosed Xenopus oocytesInhibitorinhibitorinhibit

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