2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. DBCO-PEG4-amine

DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker). DBCO-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-PEG4-amine Chemical Structure

DBCO-PEG4-amine Chemical Structure

CAS No. : 1840886-10-3

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5 mg USD 170 In-stock
10 mg USD 270 In-stock
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Based on 1 publication(s) in Google Scholar

DBCO-PEG4-amine Related Antibodies

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  • Biological Activity

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Description

DBCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker)[1]. DBCO-PEG4-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DBCO-PEG4-amine Related Antibodies
Molecular Weight

523.62

Formula

C29H37N3O6
CAS No.
Appearance

Viscous Liquid

Color

Light yellow to yellow

SMILES

O=C(NCCOCCOCCOCCOCCN)CCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (95.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9098 mL 9.5489 mL 19.0978 mL
5 mM 0.3820 mL 1.9098 mL 3.8196 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9098 mL 9.5489 mL 19.0978 mL 47.7445 mL
5 mM 0.3820 mL 1.9098 mL 3.8196 mL 9.5489 mL
10 mM 0.1910 mL 0.9549 mL 1.9098 mL 4.7745 mL
15 mM 0.1273 mL 0.6366 mL 1.2732 mL 3.1830 mL
20 mM 0.0955 mL 0.4774 mL 0.9549 mL 2.3872 mL
25 mM 0.0764 mL 0.3820 mL 0.7639 mL 1.9098 mL
30 mM 0.0637 mL 0.3183 mL 0.6366 mL 1.5915 mL
40 mM 0.0477 mL 0.2387 mL 0.4774 mL 1.1936 mL
50 mM 0.0382 mL 0.1910 mL 0.3820 mL 0.9549 mL
60 mM 0.0318 mL 0.1591 mL 0.3183 mL 0.7957 mL
80 mM 0.0239 mL 0.1194 mL 0.2387 mL 0.5968 mL
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DBCO-PEG4-amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBCO-PEG4-amine1840886-10-3ADC LinkerPROTAC LinkersAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesFPM-PEG4-DBCOhomobifunctionalazide-to-azidecross-linkerInhibitorinhibitorinhibit

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