2. Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis
  3. Calcium Channel Apoptosis
  4. Cycleanine

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway.

For research use only. We do not sell to patients.

Cycleanine Chemical Structure

Cycleanine Chemical Structure

CAS No. : 518-94-5

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5 mg USD 230 In-stock
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Based on 1 publication(s) in Google Scholar

Cycleanine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway[1][2].

IC50 & Target

L-type calcium channel

 

In Vitro

Cycleanine inhibits L-type Ca-current (ICaL) of single rat ventricular cardiomyocytes in a voltage- and frequency-dependent manner[1].
Cycleanine shows modestly less potency against human OSE cells (normal) than the cancer cells[2].
Cycleanine (20 μM; 48 hours) exhibits cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50s ranging from 7 to 14 μM[2].
Cycleanine (20 μM; 24 hours) results in significant PARP cleavage (a marker of apoptosis)[2].
Cycleanine (20 μM; 48 hours) causes a significant increase of the population of both early and late apoptotic cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cycleanine Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: Ovcar-8 cells, A2780 cells, Igrov-1 cells, Ovcar-4 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Exhibited cytotoxicity for Ovcar-8, A2780, Igrov-1, and Ovcar-4 cell lines with IC50 values of 10 μM, 7.6 μM, 14 μM, 7.2 μM, respectively.

Western Blot Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 24 hours
Result: Induced 1.1-fold increase in PARP-1 cleavage compared with carboplatin.

Apoptosis Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Caused a significant increase of the population of both early and late apoptotic cells.

Cell Cycle Analysis[2]

Cell Line: Ovcar-8 cells
Concentration: 20 μM
Incubation Time: 48 hours
Result: Increased the percentage of Ovcar-8 cells in subG1.
In Vivo

Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

622.75

Formula

C38H42N2O6
CAS No.
Unlabeled Cas

Appearance

Solid

Color

White to off-white

SMILES

COC1=C(OC2=CC=C(C[C@](N(CC3)C)([H])C4=C3C=C5OC)C=C2)C([C@@](N6C)([H])CC7=CC=C(OC4=C5OC)C=C7)=C(CC6)C=C1OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (8.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6058 mL 8.0289 mL 16.0578 mL
5 mM 0.3212 mL 1.6058 mL 3.2116 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6058 mL 8.0289 mL 16.0578 mL 40.1445 mL
5 mM 0.3212 mL 1.6058 mL 3.2116 mL 8.0289 mL
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Cycleanine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cycleanine518-94-5Calcium ChannelApoptosisCa2+ channelsCa channelsVascularcalciumICaLanalgesicanti-ovarianapoptosisInhibitorinhibitorinhibit

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